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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases

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de Araujo, Gabriela Ribeiro [1] ; dos Santos Costa, Sara Ferreira [1] ; Mesquita, Ricardo Alves [1] ; Gomez, Ricardo Santiago [1] ; dos Santos, Jean Nunes [2] ; Rebelo Pontes, Helder Antonio [3] ; Benevenuto de Andrade, Bruno Augusto [4] ; Romanach, Mario Jose [4] ; Agostini, Michelle [4] ; Vargas, Pablo Agustin [5, 6] ; Bardalez Lopez de Caceres, Cinthia Veronica [6] ; Santos-Silva, Alan Roger [6] ; Prado Ribeiro, Ana Carolina [7] ; Brandao, Thais Bianca [7] ; Tomasi, Ramiro Alejandro [8] ; Ferreyra, Ruth Salome [8] ; de Almeida, Oslei Paes [6] ; Fonseca, Felipe Paiva [1, 5]
Total Authors: 18
Affiliation:
[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil
[2] Univ Fed Bahia, Sch Dent, Dept Oral Surg & Pathol, Salvador, BA - Brazil
[3] Fed Univ Para, Joao de Barros Barreto Univ Hosp, Serv Oral Pathol, Belem, Para - Brazil
[4] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, Rio De Janeiro - Brazil
[5] Univ Pretoria, Sch Dent, Dept Oral Biol & Oral Pathol, Pretoria - South Africa
[6] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept Pathol & Semiol Areas, Piracicaba - Brazil
[7] Inst Canc Estado Sao Paulo, Dent Oncol Serv, Sao Paulo - Brazil
[8] Natl Univ Cordoba, Dent Sch, Dept Pathol, Cordoba - Argentina
Total Affiliations: 8
Document type: Journal article
Source: Head and Neck Pathology; JUN 2021.
Web of Science Citations: 0
Abstract

Smooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients' pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for alpha-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H\&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis. (AU)

FAPESP's process: 20/03818-8 - Clinicopathological, molecular and prognostic study of oral myofibroblastic neoplasms
Grantee:Oslei Paes de Almeida
Support type: Regular Research Grants