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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome profiling of fluoroquinolone-resistant uropathogenic Escherichia coli isolates from Brazil

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Author(s):
da Silva, Patrick [1] ; Lustri, Bruna C. [1] ; Castilho, Ivana Giovannetti [2] ; Ferreira, Adriano Martison [3] ; Hernandes, Rodrigo T. [2] ; Schembri, Mark A. [4] ; Moreira, Cristiano G. [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Chem & Biol Sci, Botucatu, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Med, Clin Anal Lab, Botucatu, SP - Brazil
[4] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld - Australia
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Journal of Microbiology; JUN 2021.
Web of Science Citations: 0
Abstract

Urinary tract infections (UTIs) are a major public health concern in both community and hospital settings worldwide. Uropathogenic Escherichia coli (UPEC) is the main causative agent of UTI and increasingly associated with antibiotic resistance. Herein, we report the draft genome sequence of 9 fluoroquinolone-resistant UPEC isolates from Brazil and examine selected major phenotypic features, such as antimicrobial resistance profile, phylogroup, serotype, sequence type (ST), virulence genes, and resistance marks. Besides the quinolone resistance, beta-lactams, ESBL production, aminoglycosides, and tetracycline resistance were observed. High prevalence of 20 virulence genes was detected in all isolates, such as those encoding type 1 fimbriae, acid tolerance system, and hemolysin E, particularly within E. coli B2 phylogroup, as ST131 and ST1193 strains, among other genomic analyses as genomic islands, resistance plasmids, and integron identification. (AU)

FAPESP's process: 19/03049-7 - Transcriptome of the bacterial chemical signaling in Salmonella Typhimurium, emergent global bacterial enteropathogens investigation in São Paulo, and alternative infection model employed to study pathogenesis
Grantee:Cristiano Gallina Moreira
Support type: Regular Research Grants
FAPESP's process: 14/06779-2 - Role of chemical signaling and auxiliary mechanisms in Salmonella enterica serovar Typhimurium virulence and other enteropathogens
Grantee:Cristiano Gallina Moreira
Support type: Research Grants - Young Investigators Grants