| Full text | |
| Author(s): |
Sa, Jamile De Oliveira
[1, 2]
;
Trino, Luciana Daniele
[1]
;
Oliveira, Ana Karina
[1]
;
Busso Lopes, Ariane Fidelis
[1]
;
Granato, Daniela Campos
[1]
;
Costa Normando, Ana Gabriela
[1, 2]
;
Santos, Erison Santana
[1, 2]
;
Neves, Leandro Xavier
[1]
;
Carnielli, Carolina Moretto
[1]
;
Paes Leme, Adriana Franco
[1]
Total Authors: 10
|
| Affiliation: | [1] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Biociencias LNBio, BR-13083100 Campinas, SP - Brazil
[2] Univ Estadual Campinas UNICAMP, Fac Odontol Piracicaba, Dept Diagnost Oral, Piracicaba - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | EXPERT REVIEW OF PROTEOMICS; v. 18, n. 4, p. 261-284, APR 3 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Introduction: Oral squamous cell carcinoma (OSCC) ranks among the top 10 leading causes of cancer worldwide, with 5-year survival rate of about 50%, high lymph node metastasis, and relapse rates. The OSCC diagnosis, prognosis, and treatment are mostly based on the clinical TNM classification. There is an urgent need for the discovery of biomarkers and therapeutic targets to assist in the clinical decision-making process. Areas covered: We summarize proteomic studies of the OSCC tumor, immune microenvironment, potential liquid biopsy sites, and post-translational modifications trying to retrieve information in the discovery and verification or (pre)validation phases. The search strategy was based on the combination of MeSH terms and expert refinement. Expert opinion: Untargeted combined with targeted proteomics are strategies that provide reliable and reproducible quantitation of proteins and are the methods of choice of many groups worldwide. Undoubtedly, proteomics has been contributing to the understanding of OSCC progression and uncovers potential candidates as biomarker or therapeutic targets. Nevertheless, none of these targets are available in the clinical practice yet. The scientific community needs to overcome the limitations by investing in robust experimental designs to strengthen the value of the findings, leveraging the translation of knowledge, and further supporting clinical decisions. (AU) | |
| FAPESP's process: | 18/11958-4 - Proteomic Analysis of Extracellular Vesicles from Saliva and Plasma of Patients with Squamous Cells Carcinoma and the Study of Post-Translational Modifications and Identification of Disease Markers |
| Grantee: | Leandro Xavier Neves |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/21815-9 - Multiplex N-terminomics analysis of cardiomyocyte secretome based on MMP-2 and ADAM17 activity using TMT-TAILS quantitative proteomics |
| Grantee: | Ariane Fidelis Busso Lopes |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/18496-6 - The role of alcohol treated-extracellular vesicles in oral cells transformation |
| Grantee: | Adriana Franco Paes Leme |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/12194-8 - Immobilization of multiple potential biomarkers, pure and obtained from liquid biopsies, in Metal-Organic Frameworks (MOFs) as biosensors applied in head and neck Cancer diagnosis and prognosis |
| Grantee: | Luciana Daniele Trino Albano |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/18751-9 - Discovery and validation of prognostic candidates for oral cancer in liquid biopsies. |
| Grantee: | Daniela Campos Granato |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 19/09692-9 - Validation of target proteins associated with the progression of potentially malignant disorders into Oral Cancer |
| Grantee: | Ana Gabriela Costa Normando |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/02180-0 - Study of the glycoprotein composition in the surface of extracellular vesicles of plasma from patients with oral cancer and its correlation to prognosis |
| Grantee: | Carolina Moretto Carnielli |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/15535-0 - From discovery to validation of prognostic candidates for oral cancer in liquid biopsies |
| Grantee: | Daniela Campos Granato |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/15728-3 - Association of extracellular vesicles derived from fibroblasts with the progression of Oral Squamous Cell Carcinoma |
| Grantee: | Jamile de Oliveira Sá |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 16/19337-3 - Effect of oral cancer cell-derived extracellular vesicles in the macrophages differentiation |
| Grantee: | Ana Karina de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |