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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hybrid Atypical Enteropathogenic and Extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 Strain: A Draft Genome

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Munhoz, Danielle D. [1] ; Santos, Fernanda F. [2, 3] ; Mitsunari, Thais [1] ; Schuroff, Paulo A. [1] ; Elias, Waldir P. [1] ; Carvalho, Eneas [1] ; Piazza, Roxane M. F. [1]
Total Authors: 7
[1] Inst Butantan, Lab Bacteriol, BR-05503900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04023062 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Lab Alerta, Disciplina Infectol, BR-04039032 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PATHOGENS; v. 10, n. 4 APR 2021.
Web of Science Citations: 0

Diarrheagenic Escherichia coli is the major bacterial etiological agent of severe diarrhea and a major concern of public health. These pathogens have acquired genetic characteristics from other pathotypes, leading to unusual and singular genetic combinations, known as hybrid strains and may be more virulent due to a set of virulence factors from more than one pathotype. One of the possible combinations is with extraintestinal E. coli (ExPEC), a leading cause of urinary tract infection, often lethal after entering the bloodstream and atypical enteropathogenic E. coli (aEPEC), responsible for death of thousands of people every year, mainly children under five years old. Here we report the draft genome of a strain originally classified as aEPEC (BA1250) isolated from feces of a child with acute diarrhea. Phylogenetic analysis indicates that BA1250 genome content is genetically closer to E. coli strains that cause extraintestinal infections, other than intestinal infections. A deeper analysis showed that in fact this is a hybrid strain, due to the presence of a set of genes typically characteristic of ExPEC. These genomic findings expand our knowledge about aEPEC heterogeneity allowing further studies concerning E. coli pathogenicity and may be a source for future comparative studies, virulence characteristics, and evolutionary biology. (AU)

FAPESP's process: 18/06610-9 - Pathogenicity of Escherichia coli strains that share characteristics of enteroaggregative and uropathogenic categories
Grantee:Waldir Pereira Elias Junior
Support type: Regular Research Grants
FAPESP's process: 17/25406-0 - Recombinant antibodies against bacterial toxins: new tools for diagnosis and therapy urinary infections caused by uropathogenic Escherichia coli
Grantee:Roxane Maria Fontes Piazza
Support type: Regular Research Grants
FAPESP's process: 17/14821-7 - Exploring novel virulence strategies in Escherichia coli
Grantee:Tânia Aparecida Tardelli Gomes do Amaral
Support type: Research Projects - Thematic Grants