Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update

Author(s)

Loren, Pia ^[1] ; Saavedra, Nicolas ^[1] ; Saavedra, Kathleen ^[1] ; Zambrano, Tomas ^[2] ; Moriel, Patricia ^[3] ; Salazar, Luis A. ^[1]

Affiliation

^[1] Univ La Frontera, Ctr Mol Biol & Pharmacogenet, Sci & Technol Bioresource Nucleus, Temuco 4811230 - Chile

^[2] Univ Chile, Fac Med, Dept Med Technol, Santiago 8380453 - Chile

^[3] Univ Estadual Campinas, Fac Pharmaceut Sci, BR-13083970 Campinas, SP - Brazil

• Document type: Review article
• Source: PHARMACEUTICALS; v. 14, n. 6 JUN 2021.
• Web of Science Citations: 0

Abstract

Cisplatin is an antineoplastic drug used for the treatment of many solid tumors. Among its various side effects, nephrotoxicity is the most detrimental. In recent years, epigenetic regulation has emerged as a modulatory mechanism of cisplatin-induced nephrotoxicity, involving non-coding RNAs, DNA methylation and histone modifications. These epigenetic marks alter different signaling pathways leading to damage and cell death. In this review, we describe how different epigenetic modifications alter different pathways leading to cell death by apoptosis, autophagy, necroptosis, among others. The study of epigenetic regulation is still under development, and much research remains to fully determine the epigenetic mechanisms underlying cell death, which will allow leading new strategies for the diagnosis and therapy of this disease. (AU)

• FAPESP's process: 19/13250-1 - Cisplatin-induced nephrotoxicity: contribution of clinical, genetic and epigenetic factors
• Grantee: Patricia Moriel
• Support Opportunities: Regular Research Grants