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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Beta-alanine did not improve high-intensity performance throughout simulated road cycling

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Perim, Pedro [1, 2, 3] ; Gobbi, Nathan [1, 2, 3] ; Duarte, Breno [1, 2, 3] ; Farias de Oliveira, Luana [1, 2, 3] ; Costa, Luiz Augusto Riani [1, 2, 3] ; Sale, Craig [4] ; Gualano, Bruno [5, 1, 2, 3] ; Dolan, Eimear [1, 2, 3] ; Saunders, Bryan [1, 6, 2, 3]
Total Authors: 9
[1] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Div Rheumatol, Sao Paulo, SP - Brazil
[4] Nottingham Trent Univ, Musculoskeletal Physiol Res Grp, Sport Hlth & Performance Enhancement Res Ctr, Nottingham - England
[5] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Orthopaed & Traumatol, Fac Med FMUSP, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: European Journal of Sport Science; JUN 2021.
Web of Science Citations: 0

This study investigated the effect of beta-alanine supplementation on short-duration sprints and final 4-km simulated uphill cycling time-trial performance during a comprehensive and novel exercise protocol representative of the demands of road-race cycling, and determined if changes were related to increases in muscle carnosine content. Seventeen cyclists (age 38 +/- 9 y, height 1.76 +/- 0.07 m, body mass 71.4 +/- 8.8 kg, V?O-2max 52.4 +/- 8.3 ml center dot kg(-1)center dot min(-1)) participated in this placebo-controlled, double-blind study. Cyclists undertook a prolonged intermittent cycling protocol lasting 125 min, with a 10-s sprint every 20 min, finishing with a 4-km time-trial at 5% simulated incline. Participants completed two familiarization sessions, and two main sessions, one pre-supplementation and one post-supplementation following 28 days of 6.4 g center dot day(-1) of beta-alanine (N=11) or placebo (N=6; maltodextrin). Muscle biopsies obtained pre- and post-supplementation were analysed for muscle carnosine content. There were no main effects on sprint performance throughout the intermittent cycling test (all P>0.05). There was no group (P=0.69), time (P=0.50) or group x time interaction (P=0.26) on time-to-complete the 4-km time-trial. Time-to-completion did not change from pre- to post-supplementation for BA (-19.2 +/- 45.6 s, P=0.43) or PL (+2.8 +/- 31.6 s, P=0.99). Beta-alanine supplementation increased muscle carnosine content from pre- to post-supplementation (+9.4 +/- 4.0 mmol center dot kg(-1)dm; P<0.0001) but was not related to performance changes (r=0.320, P=0.37). Chronic beta-alanine supplementation increased muscle carnosine content but did not improve short-duration sprint performance throughout simulated road race cycling, nor 4-km uphill time-trial performance conducted at the end of this cycling test. (AU)

FAPESP's process: 19/07497-4 - Effects of different types of carbohydrates during exercise on performance and metabolic responses
Grantee:Nathan Gobbi de Oliveira
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/01594-5 - Blood and muscle responses to sodium bicarbonate supplementation and subsequent exercise performance
Grantee:Pedro Henrique Lopes Perim
Support type: Scholarships in Brazil - Master
FAPESP's process: 19/06140-5 - Acute effects of b-alanine intake on regulatory mechanisms of muscle carnosine content
Grantee:Breno Duarte Costa
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/17391-0 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Pedro Henrique Lopes Perim
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support type: Research Grants - Young Investigators Grants