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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction

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Borghi-Silva, Audrey [1, 2] ; Goulart, Cassia da Luz [1] ; Carrascosa, Claudia R. [2] ; Oliveira, Cristino Carneiro [3] ; Berton, Danilo C. [4] ; de Almeida, Dirceu Rodrigues [5] ; Nery, Luiz Eduardo [2] ; Arena, Ross [6] ; Neder, J. Alberto [7, 2, 8]
Total Authors: 9
[1] Fed Univ Sao Carlos UFSCar, Cardiopulmonary Physiotherapy Lab, Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Pulm Funct & Clin Exercise Physiol Unit, Div Resp Dis, Dept Med, Sao Paulo - Brazil
[3] Univ Fed Juiz de Fora, Postgrad Program Collect Hlth, Juiz De Fora - Brazil
[4] Fed Univ Rio Grande, Pulm Physiol Unit, Porto Alegre - Brazil
[5] Fed Univ Sao Paulo UNIFESP, Div Cardiol, Dept Med, Sao Paulo - Brazil
[6] Univ Illinois, Dept Phys Therapy, Coll Appl Hlth Sci, Chicago, IL - USA
[7] Queens Univ, Kingston, ON - Canada
[8] Kingston Hlth Sci Ctr, Resp Invest Unit, Div Respirol, Dept Med, Kingston, ON - Canada
Total Affiliations: 8
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, JUN 21 2021.
Web of Science Citations: 0

Background: Respiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake ((V)over dotO(2)) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF). Methods: Ten male patients (HFrEF = 26 +/- 9%, age 50 +/- 13 years, and body mass index 25 +/- 3 kg m(2)) underwent two constant work rate tests at 80% peak of maximal cardiopulmonary exercise test to tolerance under PAV and sham ventilation. Post-exercise kinetics of (V)over dotO(2), vastus lateralis deoxyhemoglobin ({[}deoxy-Hb + Mb]) by near-infrared spectroscopy, and cardiac output (Q(T)) by impedance cardiography were assessed. Results: PAV prolonged exercise tolerance compared with sham (587 +/- 390 s vs. 444 +/- 296 s, respectively; p = 0.01). PAV significantly accelerated (V)over dotO(2) recovery (tau = 56 +/- 22 s vs. 77 +/- 42 s; p < 0.05), being associated with a faster decline in Delta{[}deoxy-Hb + Mb] and Q(T) compared with sham (tau = 31 +/- 19 s vs. 42 +/- 22 s and 39 +/- 22 s vs. 78 +/- 46 s, p < 0.05). Faster off-exercise decrease in Q(T) with PAV was related to longer exercise duration (r = -0.76; p < 0.05). Conclusion: PAV accelerates the recovery of central hemodynamics and muscle oxygenation in HFrEF. These beneficial effects might prove useful to improve the tolerance to repeated exercise during cardiac rehabilitation. (AU)

FAPESP's process: 15/26501-1 - Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach
Grantee:Audrey Borghi e Silva
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF
Grantee:Cássia da Luz Goulart
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)