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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Topical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us?

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Author(s):
Mojeiko, Gabriela [1] ; Passos, Julia Sapienza [1] ; Apolinario, Alexsandra Conceicao [1] ; Lopes, Luciana Biagini [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Nanomedicine; JUL 2021.
Web of Science Citations: 0
Abstract

Despite the high incidence of breast cancer, there are few pharmacological prevention strategies for the high-risk population and those that are available have low adherence. Strategies that deliver drugs directly to the breasts may increase drug local concentrations, improving efficacy, safety and acceptance. The skin of the breast has been proposed as an administration route for local transdermal therapy, which may improve drug levels in the mammary tissue, due to both deep local penetration and percutaneous absorption. In this review, we discuss the application of nanotechnology-based strategies for the delivery of well established and new agents as well as drug repurposing using the topical transdermal route to improve the outcomes of preventive therapy for breast cancer. (AU)

FAPESP's process: 18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors
Grantee:Luciana Biagini Lopes
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 19/00196-9 - Topical delivery of endoxifene and celecoxib using nanogels as a new alternative for the chemoprevention of breast tumors
Grantee:Gabriela Mojeiko
Support type: Scholarships in Brazil - Master
FAPESP's process: 18/14375-0 - Nanotechnology-based topical delivery systems for breast cancer chemoprevention
Grantee:Alexsandra Conceição Apolinário
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 20/01208-8 - Bioadhesive nanostructured systems for intraductal administration and localized treatment of Breast Cancer
Grantee:Julia Sapienza Passos
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support type: Research Projects - Thematic Grants