Systemic antioxidant and anti-inflammatory effects of yellow passion fruit bagasse extract during prostate cancer progression

Author(s)

Baseggio, Andressa Mara ^[1] ; Kido, Larissa Akemi ^[1] ; Vigano, Juliane ^[2] ; Carneiro, Mara Junqueira ^[3] ; Lamas, Celina de Almeida ^[4] ; Martinez, Julian ^[2] ; Sawaya, Alexandra Christine Helena Frankland ^[5] ; Cagnon, Valeria Helena Alves ^[4] ; Marostica Junior, Mario Roberto ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Fac Food Engn, Dept Food & Nutr, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Food Engn, Dept Food Engn, Campinas - Brazil

^[3] Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, Campinas - Brazil

^[4] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil

^[5] State Univ Campinas UNICAMP, Fac Pharmaceut Sci, Campinas - Brazil

• Document type: Journal article
• Source: JOURNAL OF FOOD BIOCHEMISTRY; AUG 2021.
• Web of Science Citations: 0

Abstract

We evaluated the impact of yellow passion fruit (Passiflora edulis sp.) bagasse extract (PFBE) administration in systemic oxidative and inflammatory parameters in vivo, considering prostate cancer progression in transgenic mice (TRAMP). Piceatannol, scirpusin-B, dicaffeoylquinic acid, citric acid, and (+)-catechin were identified in PFBE, and the extract showed high in vitro antioxidant capacity. Some alterations in systemic parameters were verified during prostate cancer progression, as the increase in ALT and MDA levels, and SOD and GPx activities in the plasma. In the liver, higher MDA, TNF-alpha, and NF-kappa B levels, and GR and GPx activities were verified. Compared to their respective controls, the short- and long-term PFBE administration reduced MDA levels in the liver and plasma. The long-term treatment increased the catalase activity in the plasma, while the short-term treatment increased the hepatic SOD and catalase activities. Still, a reduction in hepatic TNF-alpha and NF-kappa B levels was verified after long-term treatment. Practical applications Prostate cancer progression is associated with changes in systemic redox status and inflammation markers. Moreover, the intake of polyphenols with antioxidant properties, besides delaying prostate carcinogenesis, may improve the systemic antioxidant defenses and inflammatory response. In vitro studies pointed to a promising antioxidant and anti-inflammatory potential of yellow passion fruit bagasse. However, in vivo studies are scarce. Our results provided information about in vivo impacts of PFBE oral consumption on antioxidant defense and inflammation, indicating its potential as an adjuvant during the initial steps of prostate cancer. (AU)

• FAPESP's process: 17/01573-5 - Effects of passion fruit bagasse extract (Passiflora edulis) in vitro and in vivo: chemopreventive and anti-inflammatory role of phenolic compounds in prostate cancer progression
• Grantee: Larissa Akemi Kido de Barros
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/13465-8 - Lund University and State University of Campinas partnership for studies on cardiometabolic disease-preventive functional foods and diets
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants