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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mature T/NK-Cell lymphomas of the oral and maxillofacial region: A multi-institutional collaborative study

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Author(s):
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de Arruda, Jose Alcides Almeida [1] ; Abrantes, Thamiris de Castro [1] ; Cunha, John Lennon Silva [2] ; Roza, Ana Luiza Oliveira Correa [2] ; Agostini, Michelle [3] ; Abrahao, Aline Correa [3] ; Canedo, Nathalie Henriques Silva [4] ; Ramos, Denize D'Azambuja [4] ; Milito, Cristiane Bedran [4] ; Pontes, Flavia Sirotheau Correa [5] ; Pontes, Helder Antonio Rebelo [5] ; Barra, Marinez Bizarro [6] ; Zanella, Virgilio Gonzales [7] ; Martins, Marco Antonio Trevizani [8, 9] ; Martins, Manoela Domingues [8, 9] ; Israel, Monica Simoes [10, 11] ; Freire, Nathalia de Almeida [11] ; Barreto, Maria Eduarda Zeraik [11] ; Sanchez-Romero, Celeste [2] ; Carlos, Roman [12] ; Abreu, Lucas Guimaraes [13] ; Vargas, Pablo Agustin [2] ; de Almeida, Oslei Paes [2] ; Fonseca, Felipe Paiva [1] ; Romanach, Mario Jose [3] ; Mesquita, Ricardo Alves [1] ; de Andrade, Bruno Augusto Benevenuto [3]
Total Authors: 27
Affiliation:
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[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil
[3] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, BR-21941902 Rio De Janeiro, RJ - Brazil
[4] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Sch Med, Dept Pathol, Rio De Janeiro - Brazil
[5] Fed Univ Para, Hosp Univ Joao Barros Barreto, Serv Oral Pathol, Belem, Para - Brazil
[6] Santa Rita Hosp, Serv Pathol, Santa Casa Misericordia Porto Alegre, Porto Alegre, RS - Brazil
[7] Santa Rita Hosp, Santa Casa Misericordia Porto Alegre, Dept Head & Neck Surg, Porto Alegre, RS - Brazil
[8] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil
[9] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Oral Med, Porto Alegre, RS - Brazil
[10] Univ Estado Rio de Janeiro, Sch Dent, Dept Diag & Therapeut, Rio De Janeiro - Brazil
[11] Fac Sao Leopoldo Mand, Postgrad Program Oral Med, Rio De Janeiro - Brazil
[12] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Sect, Guatemala City - Guatemala
[13] Univ Fed Minas Gerais, Sch Dent, Dept Childrens & Adolescents Oral Hlth, Belo Horizonte, MG - Brazil
Total Affiliations: 13
Document type: Journal article
Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 6, p. 548-557, JUL 2021.
Web of Science Citations: 0
Abstract

Background The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review. Methods Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Patients' clinical data were collected from their pathology forms. Results A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK/T-cell lymphomas, nasal type; eight (36.4%) were peripheral T-cell lymphomas, NOS; two (9.1%) were adult T-cell leukaemia/lymphomas, and one (4.5%) was an ALK-positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7 years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK/T-cell lymphoma nasal type but was absent in the other subtypes. Conclusion Among mature T/NK-cell lymphomas of the oral and maxillofacial region, extranodal NK/T-cell lymphoma, nasal type and peripheral T-cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour. (AU)

FAPESP's process: 17/14880-3 - Clinicopathological and immunohistochemical analysis of follicular lymphoid hyperplasias and lymphomas of the oral cavity
Grantee:Oslei Paes de Almeida
Support Opportunities: Regular Research Grants