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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Downregulation of miR-29b is associated with Peyronie's disease

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dos Santos, Vinicius Genuino [1, 2] ; dos Santos, Gabriel Arantes [2] ; Neto, Cristovao Barbosa [3] ; Viana, Nayara Izabel [2] ; Pimenta, Ruan [2] ; Guimaraes, Vanessa Ribeiro [2] ; Candido, Patricia [2] ; Romao, Poliana [2] ; de Camargo, Juliana A. [2] ; Leite, Katia Ramos Moreira [2] ; Srougi, Miguel [2] ; Cury, Jose [3] ; Nahas, William C. [4] ; Reis, Sabrina Thalita [2, 5]
Total Authors: 14
[1] Sao Camilo Univ Ctr, Ave Nazare 1501, BR-04263200 Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Lab Med Invest LIM55, Urol Dept, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch, Sexual Med Hosp Clin, Sao Paulo - Brazil
[4] Sao Paulo Canc Inst ICESP, Sao Paulo - Brazil
[5] Athens Univ Ctr UniAtenas, Passos, MG - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 0

Background: Peyronie's disease (PD) is characterized by the formation of fibrous plaque in tunica albuginea, causing several problems in patients. The etiology of this disease is not fully understood, and there are few effective treatments. To better understand the molecular pathways of PD, we studied miR-29b, a microRNA that could be involved with this illness. MicroRNAs are endogenous molecules that act by inhibiting messenger RNA. MiR-29b regulates 11 of 20 collagen genes and the TGF-beta 1 gene, which are related to PD progression. Methods: We compared miR-29b expression in 11 patients with PD and 14 patients without PD (control group). For the patients with PD, we utilized samples from the fibrous plaque (n = 9), from the tunica albuginea (n = 11), and from the corpus cavernosum (n = 8). For the control group, we utilized samples from the tunica albuginea (n = 14) and from the corpus cavernosum (n = 10). MiR-29b expression was determined by q-PCR. Results: We found a downregulation of miR-29b in the fibrous plaque, tunica albuginea and corpus cavernosum of patients with PD in comparison with the control group (p = 0.0484, p = 0.0025, and p = 0.0016, respectively). Conclusion: Although our study has a small sample, we showed for the first time an evidence that the downregulation of miR-29b is associated with PD. (AU)

FAPESP's process: 19/19139-5 - Evaluating the expression of miR-29b in Peyronie's disease
Grantee:Vinicius Genuino dos Santos
Support type: Scholarships in Brazil - Scientific Initiation