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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endothelial function provides early prognostic information in patients with COVID-19: A cohort study

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Oliveira, Murilo Rezende [1] ; Back, Guilherme Dionir [1] ; Goulart, Cassia da Luz [1] ; Domingos, Bianca Cristina [1] ; Arena, Ross [2, 3] ; Borghi-Silva, Audrey [2, 1]
Total Authors: 6
[1] Univ Fed Sao Carlos, Cardiopulm Physiotherapy Lab, Physiotherapy Dept, UFSCar, Rodovia Washington Luis, KM 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, Chicago, IL - USA
[3] Hlth Living Pandem Event Protect HL Pivot Network, Chicago, IL - USA
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 1

Background: The prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 reflect endothelial dysfunction, which is linked to blood flow delivery deficiencies and cardiovascular risk. Assessments of detect vascular deficiencies among newly diagnosed and hospitalized patients due to COVID-19 have yet to be determined. Objective: To assess endothelial function characteristics in relation to length of hospitalization and mortality in patients diagnosed with COVID-19 and compare to patients without COVID-19. Methods: A prospective observational study involving 180 patients with confirmed COVID-19 (COVID-19 group) or suspected and ruled out COVID-19 (Non-COVID-19 group). Clinical evaluation and flow mediated vasodilation (FMD) were performed between the first 24-48 h of hospitalization. Patients were followed until death or discharge. Results: We evaluated 98 patients (COVID-19 group) and 82 (Non-COVID-19 group), COVID-19 group remained hospitalized longer and more deaths occurred compared to the Non-COVID-19 group (p = 0.01; and p < 0.01). Patients in COVID-19 group also had a significantly greater reduction in both FMDmm and FMD% (p < 0.01 in both). We found that absolute FMD=0.26 mm and relative FMD=3.43% were the ideal cutoff point to predict mortality and longer hospital stay. In Kaplan Meyer's analysis patients had a high probability of death within a period of up to 10 days of hospitalization. Conclusion: Patients hospitalized for COVID-19 present endothelial vascular dysfunction early, remained hospitalized longer and had a higher number of deaths, when compared with patients without COVID-19. (AU)

FAPESP's process: 15/26501-1 - Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach
Grantee:Audrey Borghi e Silva
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF
Grantee:Cássia da Luz Goulart
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)