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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biopolymer-based microparticles for encapsulation of all-trans-retinoic acid

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Author(s):
Silva, Leticia A. [1] ; Dambros, Roberta [1] ; Leonardi, Gislaine R. [2] ; Perrechil, Fabiana [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Engn Quim, Diadema, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 138, n. 45 DEC 5 2021.
Web of Science Citations: 0
Abstract

This work aims to investigate the potential of complex coacervation technique to encapsulate and protect all-trans retinoic acid (RA). Gelatin and kappa-carrageenan were used as wall material and pequi oil was employed as a hydrophobic phase. Three formulations with different protein: polysaccharide ratio and pH were defined to produce the microparticles based on the zeta potential and turbidity analysis: (F1) ratio 3:1 and pH 3.5, (F2) ratio 8:1 and pH 3.5, and (F3) ratio 8:1 and pH 5.0. Microparticles were evaluated regarding their morphology, yield, encapsulation efficiency (EE), and stability. The properties of microparticles were mainly affected by the protein: polysaccharide ratio and the turbidity of the mixtures, which is directly related to the protein-polysaccharide interaction. Formulation 1 showed the optimal values of yield (75.6%), EE (100.2%), and stability (85% of the encapsulated RA remained in the particle). The results demonstrated the high potential of this innovative technique to encapsulate RA for a future application in topical formulations. (AU)

FAPESP's process: 15/02129-6 - DEVELOPMENT AND EVALUATION OF RETINOIC ACID DRUG DELIVERY SYSTEMS PROVIDED BY MICROPARTICLES OF K-CARRAGEENAN IN EMULSIFIED SYSTEMS CONSTITUTED, OR NOT, OF LIQUID CRISTALLINE STRUCTURES
Grantee:Gislaine Ricci Leonardi
Support type: Regular Research Grants