| Full text | |
| Author(s): |
Alberca, Ricardo W.
[1]
;
Gomes, Eliane
[1]
;
Moretti, Eduardo H.
[1]
;
Russo, Momtchilo
[1]
;
Steiner, Alexandre A.
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Immunology Letters; v. 237, p. 27-32, SEP 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Although hypothermia has received substantial attention as an indicator of severity in anaphylaxis, it has been neglected from the perspective of whether it could act as a disease-modifying factor in this condition. Here, the impact of naturally occurring (spontaneous) hypothermia on anaphylaxis was evaluated in a murine model of ovalbumin (OVA)-induced allergy. Nonextreme changes in the ambient temperature (T-a) were used to modulate the magnitude of spontaneous hypothermia. At a T-a of 24 degrees C, challenge with OVA intraperitoneally or intravenously resulted in a rapid, transient fall in body core temperature, which reached its nadir 4-6 degrees C below baseline in 30 min. This hypothermic response was largely attenuated when the mice were kept at a Ta of 34 degrees C. The T-a-dependent attenuation of hypothermia resulted in a survival rate of only 30%, as opposed to survival of 100% in the condition that favored the development of hypothermia. The protective effect of hypothermia did not involve changes in the rate of mast cell degranulation, as assessed by the concentration of mast cell protease-1 in bodily fluids. On the other hand, hypothermia improved oxygenation of the brain and kidneys, as indicated by higher NAD(+)/NADH ratios. Therefore, it is plausible to propose that naturally occurring hypothermia makes organs more resistant to the anaphylactic insult. (AU) | |
| FAPESP's process: | 20/09399-7 - Development of hypothermia in systemic inflammation: the brain hypoxia hypothesis |
| Grantee: | Eduardo Hermogenes Moretti |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/08699-7 - Characterization of specific T follicular helper cell upon sensitization with Ovalbumin associated with different adjuvants |
| Grantee: | Ricardo Wesley Alberca Custódio |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 13/24694-1 - Immunotherapy of experimental asthma by agonists of toll-like receptors, infection or tolerance |
| Grantee: | Momtchilo Russo |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/03418-0 - Hypothermia in Sepsis: causes and consequences |
| Grantee: | Alexandre Alarcon Steiner |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/16602-8 - Immunotherapy in experimental asthma by CpG |
| Grantee: | Ricardo Wesley Alberca Custódio |
| Support Opportunities: | Scholarships in Brazil - Doctorate |