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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nandrolone decanoate and resistance exercise affect body composition and energy metabolism

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Author(s):
Pozzi, Renan [1, 2] ; Fernandes, Leandro [2] ; da Silva, Vanessa Cavalcante [2] ; D'Almeida, Vania [2]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Dept Psychobiol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Steroids; v. 174, OCT 2021.
Web of Science Citations: 0
Abstract

Our aim was to evaluate the independent and associated effects of nandrolone decanoate (DECA) and resistance exercise (REx) on central and peripheral hormones and neuropeptides related to energy balance in male rats. The experimental protocol was performed for eight weeks and comprised four groups: control (C) - exposed to vehicle 3x/wk; trained (T) - REx 5x/wk and vehicle 3x/wk; decanoate (D) - exposed to DECA (5 mg/kg) 3x/wk, and REx with DECA (TD) - submitted to REx 5x/wk and DECA (5 mg/kg) 3x/wk. Cross-sectional area analysis of the gastrocnemius muscle was higher in the T and TD groups compared to the C group. Biometrical analyses showed a decrease in body weight only in the TD compared to the C group, however, a reduction in total fat mass was observed in both the T and TD when compared to the C group. In respect of hypothalamic mRNA expression, there was an increase in prepro-orexin in the T compared to the C group. In mesenteric fat there was a decrease in leptin expression in the T and TD compared to the C group. Plasma evaluations showed reduced leptin concentrations in D, T and TD compared to C, and an increase in orexin-A in the D group compared to the C and T groups. Our data showed that REx was related to central and peripheral changes in energy metabolism, while DECA changed only peripheral components. REx associated with DECA promoted peripheral changes in energy metabolism and decreased body and fat weights. (AU)

FAPESP's process: 13/05549-0 - Central and peripheral changes on energy balance in rats submitted to resistance training and exposed to nandrolone decanoate
Grantee:Renan Pozzi
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/17587-4 - Central and peripheral changes on energy balance in rats submitted to resistance training and exposed to nandrolone decanoate
Grantee:Vânia D'Almeida
Support Opportunities: Regular Research Grants