Transcriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapy

Author(s)

Camargo, Ana C. L. ^[1] ; Remoli, Beatriz ^[1] ; Portela, Luiz M. F. ^[1] ; Fioretto, Mateus N. ^[1] ; Chuffa, Luiz G. A. ^[1] ; Moreno, Carlos S. ^{[2, 3]} ; Justulin, Luis A. ^[1]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Dept Struct & Funct Biol, Inst Biosci, BR-18618689 Botucatu, SP - Brazil

^[2] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 - USA

^[3] Emory Univ, Dept Biomed Informat, Sch Med, Atlanta, GA - USA

• Document type: Journal article
• Source: Molecular and Cellular Endocrinology; v. 535, SEP 15 2021.
• Web of Science Citations: 0

Abstract

Reproductive cancers in both genders represent serious health problems, whose incidence has significantly risen over the past decades. Although considerable differences among reproductive cancers exist, we aimed to identify similar signaling pathways and key molecular oncomarkers shared among six human reproductive cancers that can advance the current knowledge of cancer biology to propose new strategies for more effective therapies. Using a computational analysis approach, here we uncover aberrant miRNAs-mRNAs networks shared in six reproductive tumor types, and identify common molecular mechanisms strictly associated with cancer promotion and aggressiveness. Based on the fact that estrogenic and androgenic signaling pathways were most active in prostate and breast cancers, we further demonstrated that both androgen and estrogen deprivation therapy are capable of regulating the expression of the same key molecular sensors associated with endoplasmic reticulum dysfunction and cell cycle in these cancers. Overall, our data reveal a potential mechanistic framework of cellular processes that are shared among reproductive cancers, and particularly, highlight the importance of hormonal deprivation in breast and prostate cancers and potentially new biomarkers of response to these therapeutic approaches. (AU)

• FAPESP's process: 18/09408-6 - RNA-seq analysis to identify molecular targets involved in deregulation of prostate morphogenesis in rat offspring submitted to maternal low protein diet.
• Grantee: Ana Carolina Lima Camargo
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 17/01063-7 - Integrative global analyzes of the rat ventral prostate submitted to maternal protein restriction and its repercussions with aging
• Grantee: Luis Antonio Justulin Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/08715-0 - Integrative analysis of the transcriptome and proteomics of the ventral prostate of rat offspring submitted to maternal protein restriction
• Grantee: Ana Carolina Lima Camargo
• Support Opportunities: Scholarships in Brazil - Doctorate