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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer

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Melo, Carina Mucciolo [1, 2] ; Wang, Huawei [3] ; Fujimura, Ken [3] ; Strnadel, Jan [4] ; Meneghetti, Maria Cecilia Zorel [2] ; Nader, Helena Bonciani [2] ; Klemke, Richard L. [3] ; Pinhal, Maria Aparecida Silva [1, 2]
Total Authors: 8
[1] Fac Med ABC, Dept Biochem, Santo Andre, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biochem Mol Biol, Sao Paulo - Brazil
[3] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 - USA
[4] Comenius Univ, Jessenius Fac Med Martin, Biomed Ctr Martin, Dept Mol Med, Martin - Slovakia
Total Affiliations: 4
Document type: Journal article
Source: FRONTIERS IN ONCOLOGY; v. 11, AUG 4 2021.
Web of Science Citations: 0

Angiogenesis is the formation of new vessels from pre-existing vasculature. The heparan sulfate chains from endothelial cell proteoglycans interact with the major angiogenic factors, regulating blood vessels ` formation. Since the FDA ` s first approval, anti-angiogenic therapy has shown tumor progression inhibition and increased patient survival. Previous work in our group has selected an HS-binding peptide using a phage display system. Therefore, we investigated the effect of the selected peptide in angiogenesis and tumor progression. The HS-binding peptide showed a higher affinity for heparin N-sulfated. The HS-binding peptide was able to inhibit the proliferation of human endothelial umbilical cord cells (HUVEC) by modulation of FGF-2. It was verified a significant decrease in the tube formation of human endothelial cells and capillary formation of mice aorta treated with HS-binding peptide. HS-binding peptide also inhibited the formation of sub-intestinal blood vessels in zebrafish embryos. Additionally, in zebrafish embryos, the tumor size decreased after treatment with HS-binding peptide. (AU)

FAPESP's process: 19/03024-4 - Effect of antioxidants on modulation of lipoprotein lipase by alteration of heparan sulfate proteoglycans in endothelial cells
Grantee:Carina Mucciolo Melo
Support type: Regular Research Grants
FAPESP's process: 16/01357-8 - Heparan sulfate, heparanase and HER2 binding peptides with potential antineoplastic effect
Grantee:Maria Aparecida da Silva Pinhal
Support type: Regular Research Grants