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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrochemical determination of melatonin using disposable self-adhesive inked paper electrode

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Freitas, Rafaela C. [1] ; Orzari, Luiz O. [1, 2] ; Ferreira, Luis M. C. [3] ; Paixao, Thiago R. L. C. [4] ; Coltro, Wendell K. T. [5] ; Vicentini, Fernando C. [3] ; Janegitz, Bruno C. [1]
Total Authors: 7
[1] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Phys Chem & Math, BR-18052780 Sao Paulo - Brazil
[3] Univ Fed Sao Carlos, Ctr Nat Sci, Rod Lauri Simoes Barros Km 12, Buri, SP - Brazil
[4] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-05508000 Sao Paulo, SP - Brazil
[5] Univ Fed Goias, Inst Chem, BR-74690900 Goiania, Goias - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 0

Melatonin is a hormone that affects sleep-wake cycles and plays a role in the understanding of neuronal disorders and has excellent potential for therapeutical applications in infectious diseases, becoming an important target of chemical analysis. In this context, we report the development of an electrochemical device comprising a self-adhesive electrode based on a graphite-automotive varnish (Gr-AV) mixture as a conducive material to produce a printable ink applied over a paper adhesive easily transferred to a polyethylene terephthalate substrate. The Gr-AV electrode presented a high electrochemically active surface area which showed to be suitable for melatonin oxidation. The association of the device alongside a square-wave voltammetry method offered a linear behavior in the concentration range from 10.0 to 100.0 mu mol L-1, a limit of detection of 0.49 mu mol L-1, as well as presenting exciting recovery and relative standard deviation over samples analysis. The results showed the valid application of the device for the determination of melatonin in biological samples, pharmaceutical formulations, and its potential for point-of-care analysis. (AU)

FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
Grantee:Osmar Malaspina
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 19/24428-6 - Development of Pd and Ag binary materials for modification of the glassy carbon electrode and disposable printed electrode for melatonin and nitrite determination
Grantee:Rafaela Cristina de Freitas
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/23342-0 - Development of novel immunosensor architechtures for the detection of Huntington and Parkinson Diseases biomarkers
Grantee:Luiz Otávio Orzari
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications
Grantee:Mauro Bertotti
Support type: Research Projects - Thematic Grants