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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aqueous synthesis of magnetite nanoparticles for magnetic hyperthermia: Formation mechanism approach, high water-dispersity and stability

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Perecin, Caio J. [1, 2] ; Tirich, Beatriz M. [1] ; Nagamine, Luiz C. C. M. [3] ; Porto, Gabriela [4] ; V. Rocha, Fillipe [4] ; Cerize, Natalia N. P. [2] ; Varanda, Laudemir C. [1]
Total Authors: 7
[1] Univ Sao Paulo, Phys Chem Dept, Inst Quim Sao Carlos, Colloidal Mat Grp, BR-13566590 Sao Carlos, SP - Brazil
[2] Inst Pesquisas Tecnol, Bionanomfg Ctr, BR-05508901 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Fis, BR-05508090 Sao Paulo, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Superparamagnetic iron oxide nanoparticles (SPIONs) are interesting for biomedical applications in cancer treatment via magneto-hyperthermia. Its potential application contrasts with the challenges in producing systems with chemical and morphological uniformity and colloidal stability using simple, low-cost, and sustainable routes. Aqueous syntheses usually fail to control morphology and composition because SPIONs formation mechanisms are not fully understood. Here, we propose an aqueous route to synthesize SPIONs based on the controlled and stoichiometric reduction in situ of Fe3+ to Fe2+ ions in the presence of sulfite ions, followed by aging at 90 degrees C in an alkaline medium for 18 h. SPIONs with high water-stable and controlled characteristics in a sustainable, inexpensive, and scalable procedure were obtained. The nucleation, growth, and hydrolysis rates were adjusted by the excess of OH- ions, initial temperature, and iron precursor nature. The results are discussed concerning concepts of the classical and nonclassical nucleation theories, indicating an optimum pH of 9.5-10.5 for SPIONs formation. The SPIONs present an average size of 11 nm, narrow size distribution, and magnetite phase with about 34 mol% of maghemite due to structural defects. Nanoparticles are superparamagnetic, have a hydrodynamic diameter of 130 nm with a surface potential of similar to -40 mV (pH >= 7), and suitable magneto-hyperthermic properties fro cancer treatment. Specific Absorption Rate values were evaluated concerning the SPIONs physical-chemical properties, indicating a strong dependence on the average crystallite size and the magnetization at 250 Oe. Cell viability tests showed that SPIONs did not provide any significant change in cellular growth at used concentrations. (AU)

FAPESP's process: 20/06501-5 - Magnetic nanoparticles with enhanced hyperthermic properties for cancer treatment
Grantee:Laudemir Carlos Varanda
Support type: Regular Research Grants
FAPESP's process: 19/11242-1 - Relative quantification of DNA-Topoisomerases enzymes in cell lines: Correlation between cytotoxicity and mechanism of action of coordination compounds
Grantee:Fillipe Vieira Rocha
Support type: Regular Research Grants
FAPESP's process: 16/21371-5 - Structural, magnetic and hyperfine properties of nanoparticles of ferrites (MxFe3-xO4, M=Co, Ni, Cu or Zn) and In-Sn-O (ITO) doped with transition metals and rare-earth elements: Potential applications in hyperthermia and gas sensors
Grantee:Luiz Carlos Camargo Miranda Nagamine
Support type: Regular Research Grants
FAPESP's process: 13/01284-2 - Theranostic nanoparticles based in superparamagnetic iron oxide for skin cancer therapy by magnetic hyperthermia
Grantee:Laudemir Carlos Varanda
Support type: Regular Research Grants