| Full text | |
| Author(s): |
Santos, Nathalia Leal
[1]
;
Bustos, Silvina Odete
[1]
;
Bhatt, Darshak
[2, 1]
;
Chammas, Roger
[1]
;
Andrade, Luciana Nogueira de Sousa
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Canc Estado Sao Paulo, Hosp Clin, Ctr Translat Res Oncol, Fac Med, Sao Paulo - Brazil
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol & Infect Prevent, Groningen - Netherlands
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 9, AUG 31 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Cancer can be described as a dynamic disease formed by malignant and stromal cells. The cellular interaction between these components in the tumor microenvironment (TME) dictates the development of the disease and can be mediated by extracellular vesicles secreted by tumor cells (TEVs). In this review, we summarize emerging findings about how TEVs modify important aspects of the disease like continuous tumor growth, induction of angiogenesis and metastasis establishment. We also discuss how these nanostructures can educate the immune infiltrating cells to generate an immunosuppressive environment that favors tumor progression. Furthermore, we offer our perspective on the path TEVs interfere in cancer treatment response and promote tumor recurrence, highlighting the need to understand the underlying mechanisms controlling TEVs secretion and cargo sorting. In addition, we discuss the clinical potential of TEVs as markers of cell state transitions including the acquisition of a treatment-resistant phenotype, and their potential as therapeutic targets for interventions such as the use of extracellular vesicle (EV) inhibitors to block their pro-tumoral activities. Some of the technical challenges for TEVs research and clinical use are also presented.</p> (AU) | |
| FAPESP's process: | 19/07278-0 - Effect of miR-195 superexpression in the cargo of microRNAs present in extracellular vesicles secreted by human melanoma cells and in the regulation of sensibility to target-therapy through horizontal transfer of information |
| Grantee: | Nathalia Leal Santos |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 20/09176-8 - Assessment of response to oncolytic viral therapy in immunogenic tumors: the role of extracellular vesicles in the therapeutic outcome |
| Grantee: | Luciana Nogueira de Sousa Andrade |
| Support Opportunities: | Regular Research Grants |