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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A novel automated simulator of pediatric systemic circulation: Design and applications

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Torres, Daniel S. [1] ; Mazzetto, Marcelo [2] ; Cestari, Idagene A. [1, 2]
Total Authors: 3
[1] Univ Sao Paulo, Escola Politecn, Av Prof Luciano Gualberto 380, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Coracao, Hosp Clin HCFMUSP, Fac Med, Av Dr Eneas Carvalho Aguiar 44, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Biomedical Signal Processing and Control; v. 70, SEP 2021.
Web of Science Citations: 0

The technology of ventricular assist devices has shown unprecedented evolution over the last decade. Despite of it, there is still a great need of developing pediatric specific devices, thus highlighting the demand for flexible simulators, capable of emulating mechanical circulatory assistance in the setting of pediatric heart failure. The aim of this work was to design and build an automated simulator of the pediatric circulation. The simulator comprises a hydraulic circulation mock loop and an electronic system with its computational algorithms and its graphical user interface. The simulator includes left ventricle assist devices capable of generating pulsatile or continuous-flow. To demonstrate the applicability of the automated system developed, normal and heart failure conditions of pediatric patients were simulated and the contribution of left ventricular assist devices in restoring normal hemodynamics were quantified. Restoration of aortic flow was obtained with the use of continuous or pulsatile devices in heart failure simulated conditions. The system is user friendly and intuitive, allowing fast and reproducible adjustments of parameters, such as vascular resistance and compliance, and left ventricle preload, providing environments suitable for in vitro evaluation of pediatric left ventricle assist devices. (AU)

FAPESP's process: 14/00695-1 - Development of a mock circulatory system for the evaluation of pediatric ventricular assist devices
Grantee:Daniel Seidenberger Torres
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/50283-6 - Circulatory support in pediatric patients: ventricular assist device and extracorporeal membrane oxygenation
Grantee:Idágene Aparecida Cestari
Support type: Research Projects - Thematic Grants