Hybrid chitosan/amniotic membrane-based hydrogels for articular cartilage tissue engineering application

Author(s)

Toniato, Tatiane Venturott ^[1] ; Stocco, Thiago Domingues ^{[2, 3]} ; Martins, Danilo dos Santos ^[4] ; Santanna, Luciana Barros ^[5] ; Tim, Carla Roberta ^[6] ; Marciano, Fernanda Roberta ^[7] ; Silva-Filho, Edson Cavalcanti ^[8] ; Campana-Filho, Sergio Paulo ^[4] ; Lobo, Anderson de Oliveira ^[8]

Affiliation

^[1] Univ Vale Paraiba, Inst Res & Dev, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Sao Paulo - Brazil

^[3] Univ Santo Amaro, Fac Physiotherapy, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sao Carlos Inst Chem, Sao Paulo - Brazil

^[5] Univ Vale Paraiba, Lab Immunol, Sao Paulo - Brazil

^[6] Brasil Univ, Sci & Technol Inst, Sao Paulo - Brazil

^[7] Univ Fed Piaui, Dept Phys, Teresina, Piaui - Brazil

^[8] UFPI Fed Univ Piaui, Dept Mat Engn, LIMAV Interdisciplinary Lab Adv Mat, Teresina, Piaui - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS; v. 69, n. 15, p. 961-970, OCT 12 2020.
• Web of Science Citations: 6

Abstract

A hybrid hydrogel combining collagen and chitosan (Ch) and human amniotic membranes (AM) were produced. To produce hybrid hydrogels, a fixed concentration of chitosan (2%) was used, adding AM as a booster at the concentrations of 2.5, 5.0. and 10.0% (w/w). DSC curves showed the denaturation of collagen. The swelling capacity of hydrogels ranged between 333 +/- 19% and 368 +/- 28%. The groups Ch-1.0 mg/mL and Ch-2.0 mg/mL had an elastic modulus 27% higher than the other groups. {[}GRAPHICS] . (AU)

• FAPESP's process: 16/01584-4 - Hydrogels of amniotic membrane and poly(ethylene glycol) (PEG) to the regeneration cartilaginous tissue
• Grantee: Tatiane Venturott Toniato
• Support Opportunities: Scholarships in Brazil - Master