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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioadhesive Curcumin-Mediated Photodynamic Inactivation and Its Potential to Cause Undesirable Effects on Dental and Restorative Surfaces

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Author(s):
Reina, Barbara Donadon [1] ; Santezi Neto, Carolina ; Garcia, Patricia Petromilli Nordi Sasso [1] ; Chorilli, Marlus [2] ; Calixto, Giovana Maria Fioramonti [3] ; Dovigo, Livia Nordi [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Social Dent, Sch Dent, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharm, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, BR-14800903 Araraquara, SP - Brazil
[3] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Biosci, Ave Limeira, BR-13414903 Piracicaba, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACEUTICS; v. 13, n. 9 SEP 2021.
Web of Science Citations: 0
Abstract

Curcumin-mediated Photodynamic Inactivation (PDI) has shown great potential to disinfect specific sites on tooth enamel but may involve contact with restorative materials. Thus, before use in dentistry, it is necessary to investigate whether the PDI protocol causes undesirable changes in the surfaces of aesthetic restorative materials and dental enamel. This study investigated the effect of PDI mediated by curcumin (CUR) in a liquid crystal precursor system on color stability (Delta E), surface roughness (Ra), and microhardness (kgf) of three different composite resins and bovine dental enamel specimens. The microhardness and roughness readings were performed 60 days after the treatments while the color readings were performed immediately, 24, 48, and 72 h, 7, 14, 21, 30, and 60 days after the treatments. Results showed that CUR mediated-PDI does not seem to have the potential to promote any esthetic or mechanical changes to the surface of tooth enamel and can be applied safely in clinical practice. However, the results on color, roughness, and hardness obtained for composite resins show that some negative effects can be produced, depending on the type of restorative material; more experiments must be performed with different formulations and, perhaps, with lower concentrations of CUR. (AU)

FAPESP's process: 13/15770-6 - Efficacy of curcumin-mediated photodynamic inactivation against dental biofilms and evaluation of possible changes on the properties of composite resins and dental surface
Grantee:Carolina Santezi Neto
Support Opportunities: Scholarships in Brazil - Doctorate