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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vivo synergism of free miltefosine or in alginate-based nanocarrier combined with voriconazole on aspergillosis

Full text
Author(s):
Barreto, Thayna L. [1] ; Lopes, Luciana B. [1] ; Melo, Analy S. A. [2] ; Ishida, Kelly [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, BR-05508000 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, BR-04039032 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 16, n. 15 OCT 2021.
Web of Science Citations: 0
Abstract

Aim: To evaluate the activity of miltefosine (MFS), in its free form or loaded-alginate nanoparticles (MFS-AN), alone or combined with voriconazole (VRC) on Aspergillus fumigatus and Aspergillus flavus. Materials \& methods: Broth microdilution assay was used for susceptibility testing of Aspergillus isolates, and the antifungal efficacy was assessed using the aspergillosis model in Galleria mellonella larvae. Results: The in vitro synergistic effect of MFS with VRC was observed only against A. fumigatus, whereas both combined therapies (MFS + VRC and MFS-AN + VRC) showed synergism in reducing the larval mortality rate and fungal burden in the larvae infected by A. fumigatus and A. flavus. Conclusions: MFS and MFS-AN combined with VRC may be an important strategy for improving antifungal therapy against aspergillosis. (AU)

FAPESP's process: 17/19374-9 - Echinocandins in the control of infections associated to polymicrobial biofilms of Candida spp. and bacteria such as Stapholococcus aureus and Pseudomonas aeruginosa
Grantee:Kelly Ishida
Support Opportunities: Regular Research Grants
FAPESP's process: 15/07993-0 - ENCAPSULATION OF MILTEFOSINE INTO MICROPARTICLES OF ALGINATE AND EVALUATION OF EFFECTS "IN VITRO" AND "IN VIVO" ON MURINE MODEL OF PULMONARY CRYPTOCOCCOSIS
Grantee:Kelly Ishida
Support Opportunities: Regular Research Grants
FAPESP's process: 18/03708-8 - Antifungal efficacy of miltefosine in alginate nanocarrier in the treatment of aspergillosis
Grantee:Thayná Lopes Barreto
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors
Grantee:Luciana Biagini Lopes
Support Opportunities: Research Grants - Young Investigators Grants - Phase 2