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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prognostic molecular markers for motor recovery in acute hemorrhagic stroke: A systematic review

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Ribeiro, Jean Alex Matos [1] ; Garcia-Salazar, Luisa Fernanda [1, 2] ; Saade-Pacheco, Cassia Regina [1, 3] ; Silva, Erika Shirley Moreira [1] ; Oliveira, Simone Garcia [1] ; Silveira, Ana Flavia [1] ; Garcia-Araujo, Adriana Sanches [1] ; Russo, Thiago Luiz [1]
Total Authors: 8
[1] Univ Fed Sao Carlos, Dept Phys Therapy, Sao Carlos - Brazil
[2] Univ Rosario, Sch Med & Hlth Sci, Rehabil Sci Res Grp, Bogota - Colombia
[3] Municipal Inst Higher Educ Assis, Educ Fdn Municipal Assis, Assis - Brazil
Total Affiliations: 3
Document type: Review article
Source: Clinica Chimica Acta; v. 522, p. 45-60, NOV 2021.
Web of Science Citations: 0

Background and aims: Molecular biomarkers are associated with poor prognosis in ischemic stroke individuals. However, it might not be generalizable to post-acute hemorrhagic stroke since the underlying mechanisms of this brain damage differ from those found in ischemic stroke. The main purpose of this review was to synthesize the potential predictive molecular biomarkers for motor recovery following acute hemorrhagic stroke. Materials and methods: An electronic search was conducted by 2 independent reviewers in the following databases: PubMed (Medline), EMBASE, Web of Science, and CINAHL. We included studies that addressed the following: collected blood, urine, or cerebrospinal fluid samples within 72 h after hemorrhagic stroke and that reported the prognostic association with functional motor recovery for each molecular biomarker. Screening of titles, abstracts, and full texts and data extraction were undertaken independently by pairs of reviewers. Results: Twelve thousand, five hundred and sixty-four studies were identified and 218 were considered eligible. Finally, we included 70 studies, with 96 biomarkers analyzed, of which 61 were considered as independent prognostic biomarkers, and 10 presented controversial results. Conclusion: This systematic review shows that motor functional recovery can be predicted by 61 independent prognostic molecular biomarkers assessed in the acute phase after a hemorrhagic stroke. (AU)

FAPESP's process: 17/13655-6 - Sedentary behaviour and arterial dysfunction in chronic post-stroke subjects
Grantee:Thiago Luiz de Russo
Support Opportunities: Regular Research Grants
FAPESP's process: 17/25185-4 - The effect of the aerobic exercise associated to the modified constraint-induced movement therapy in chronic hemiparetic individuals: a randomized clinical trial
Grantee:Erika Shirley Moreira da Silva
Support Opportunities: Scholarships in Brazil - Doctorate