Increased PLA(2) activity in individuals at ultra-high risk for psychosis

Author(s)

Talib, Leda L. ^{[1, 2]} ; Costa, Alana C. ^{[1, 2]} ; Joaquim, Helena P. G. ^{[1, 2]} ; Pereira, Cicero A. C. ^{[1, 2]} ; van de Bilt, Martinus T. ^{[1, 2]} ; Loch, Alexandre A. ^{[1, 2]} ; Gattaz, Wagner F. ^{[1, 2]}

Affiliation

^[1] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBION, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sch Med, Rua Dr Ovidio Pires de Campos 785, 1st Floor, BR-05403010 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; v. 271, n. 8, p. 1593-1599, DEC 2021.
• Web of Science Citations: 0

Abstract

Phospholipase A(2) is the main enzyme in the metabolism of membrane phospholipids. It comprises a family of enzymes divided into iPLA(2), cPLA(2) and sPLA(2). Studies have reported increased PLA(2) activity in psychotic patients, which suggests an accelerated breakdown of membrane phospholipids. In the present study we investigated whether increased PLA(2) activity is also present in individuals at ultra-high risk (UHR) for psychosis. One-hundred fifty adults were included in this study (85 UHR and 65 controls). UHR was assessed using the ``structured interview for prodromal syndromes{''}. PLA(2) activity was determined in platelets by a radio-enzymatic assay. We found in UHR individuals increased activities of iPLA(2) (p < 0.001) and cPLA(2) (p = 0.012) as compared to controls. No correlations were found between socio-demographic and clinical parameters and PLA(2) activity. Our findings suggest that increased PLA(2) activities may be useful as a biological risk-marker for psychotic disorders. (AU)

• FAPESP's process: 17/26291-2 - Peripheral markers of membrane metabolism: characterization of individuals at ultra-high risk for psychosis
• Grantee: Alana Caroline Costa
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/50873-3 - INCT 2014: National Institute of Biomarkers in Neuropsychiatry
• Grantee: Wagner Farid Gattaz
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 18/11414-4 - Alterations in the inflammatory pathway of Cox: risk for the development of schizophrenia
• Grantee: Cícero Augusto Costa Pereira
• Support type: Scholarships in Brazil - Master