meso-Tetra-(4-pyridyl)porphyrin/palladium(ii) complexes as anticancer agents

Author(s)

Alves, Kamilla M. ^[1] ; Honorato, Joao ^{[2, 3]} ; Liao, Luciano M. ^[1] ; Velozo-Sa, Vivianne S. ^[4] ; Guedes, Adriana P. M. ^[3] ; Dutra, Jocely de L. ^[3] ; Ayalla, Alejando P. ^[5] ; Ellena, Javier ; Batista, Alzir A. ^{[3, 1]} ; Goncalves, Pablo J. ^{[6, 1]}

Affiliation

^[1] Univ Fed Goias, Inst Chem, Goiania, Go - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil

^[4] Univ Fed Goias, Inst Biol Sci, Goiania, Go - Brazil

^[5] Univ Ceara, Dept Phys, Fortaleza, CE - Brazil

^[6] Univ Fed Goias, Inst Phys, Goiania, Go - Brazil

• Document type: Journal article
• Source: DALTON TRANSACTIONS; v. 50, n. 44 SEP 2021.
• Web of Science Citations: 0

Abstract

This study reports the synthesis, structural characterization and cytotoxic activity of four new palladium/pyridylporphyrin complexes, with the general formula [TPyP{[}PdCl(P-P)](4)](PF6)(4), where P-P is 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), 1,2-bis(diphenylphosphino)butane (dppb) or 1,1 `-bis(diphenylphosphino)ferrocene (dppf). The complexes were characterized by elemental analysis, and by FT-IR, UV/Vis, H-1 and P-31[H-1] NMR (1D/2D) spectroscopy. The slow evaporation of a methanolic solution of [TPyP{[}PdCl(dppb)](4)](PF6)(4) (in an excess of NaBF4 salt) resulted in single crystals suitable for X ray diffraction, allowing the determination of the tridimensional structure of this complex, which crystallized in the P2(1)/a space group. The cytotoxicity of the complexes against MDA-MB-231 (breast cancer cells) and MCF-10A (non-tumor breast cancer cells), was determined by the colorimetric MTT method, which revealed that all four complexes show selective indexes close to 1.2, lower than that of cisplatin for the same cells (12.12). The interaction of the complexes with CT-DNA was evaluated by UV-visible and viscosity measurements and it was determined that the complexes interact moderately with CT-DNA, probably by H-bonding/pi-pi stacking and electrostatic interactions. (AU)

• FAPESP's process: 21/02522-0 - Multi-user equipment approved in grant 2017/15850-0: Synergy-S
• Grantee: Eduardo Ernesto Castellano
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 21/04876-4 - Studies on structure & activity of RuII / arene / mercaptoligants complexes against cancer
• Grantee: João Honorato de Araujo Neto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/19342-2 - Metal complexes with dirivative ligands of lawsone and acylthioureas, with anticancer potential activities: study in vitro and in vivo.
• Grantee: Alzir Azevedo Batista
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/15850-0 - X-ray diffraction as a tool in potential drug development
• Grantee: Eduardo Ernesto Castellano
• Support Opportunities: Research Projects - Thematic Grants