Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

caling up xylitol bioproduction: Challenges to achieve a profitable bioproces

Full text
Author(s):
Queiroz, Sarah S. [1] ; Jofre, Fanny M. [1] ; Mussatto, I, Solange ; Felipe, Maria das Gracas A. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Engn Sch Lorena, Dept Biotechnol, Estr Municipal Campinho S-N, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: RENEWABLE & SUSTAINABLE ENERGY REVIEWS; v. 154, FEB 2022.
Web of Science Citations: 0
Abstract

Xylitol is a GRAS (Generally Recognized as Safe) polyol commonly used in the food industry and able to promote several benefits to the health. In addition, it can also be used as a building block molecule for the manufacture of different high-value chemicals. Currently, the commercial production of xylitol occurs by chemical route through the catalytic hydrogenation of xylose from lignocellulosic biomass. Since this is an expensive process due to the severe reactional conditions employed, the biotechnological route for xylitol production, which comprises the biological conversion of xylose into xylitol, emerges as a potential lower-cost alternative to obtain this polyol due to the milder process conditions required. However, the biotechnological route still presents important bottlenecks and challenges that impairs the process scaling up. Modern strategies and technologies that can potentially improve xylitol bioproduction include adaptive evolution of microbial strains to enhance their tolerance to inhibitors and the xylose uptake rate during the fermentation step; development of engineered microorganisms to result in higher xylose-to-xylitol bioconversion yields; as well as xylitol purification techniques to improve the recovery yields. Moreover, techno-economic analysis of the overall production chain is essential to identify the process viability for large-scale implementation as well as the steps requiring improvements. These are some key factors discussed in this review, which aims to provide insights for the development of a more economically competitive, less energy demanding and scalable new technology for xylitol production. (AU)

FAPESP's process: 19/27092-9 - Xylitol-producing biorefinery from sugarcane: new strategies to make the biotechnological route viable
Grantee:Maria das Graças de Almeida Felipe
Support Opportunities: Program for Research on Bioenergy (BIOEN) - Regular Program Grants