Immune status, well-being and gut microbiota in military supplemented with synbiotic ice cream and submitted to field training: a randomised clinical trial

Author(s):Show less -

Valle, Maria C. P. R. ^[1] ; Vieira, Isabel A. ^[1] ; Fino, Luciana C. ^[1] ; Gallina, Darlila A. ^[2] ; Esteves, Andrea M. ^[1] ; da Cunha, Diogo T. ^[1] ; Cabral, Lucelia ^[3] ; Benatti, Fabiana B. ^[1] ; Marostica Junior, Mario R. ^[4] ; Batista, Angela G. ^{[4, 5]} ; Santos, Rosangela ^[4] ; Pastore, Glaucia M. ^[4] ; Sartoratto, Adilson ^[6] ; Sivieri, Katia ^[7] ; Tizioto, Polyana C. ^[8] ; Coutinho, Luiz L. ^[9] ; Antunes, Adriane E. C. ^[1]

Affiliation

^[1] Univ Campinas FCA UNICAMP, Sch Appl Sci, Limeira - Brazil

^[2] State Govt Sao Paulo, Food Technol Inst ITAL, Campinas, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci, Dept Gen & Appl Biol, Rio Claro - Brazil

^[4] Univ Campinas FEA UNICAMP, Fac Food Engn, Campinas, SP - Brazil

^[5] Univ Fed Santa Maria, Dept Food & Nutr, Palmeira Das Missoes, RS - Brazil

^[6] Univ Campinas CPQBA UNICAMP, Multidisciplinary Ctr Chem Biol & Agr Res, Paulinia - Brazil

^[7] Univ Sao Paulo Julio de Mesquita Filho UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[8] NGS Genom Solut, Lab Genom, Piracicaba - Brazil

^[9] Univ Sao Paulo ESALQ USP, Sch Agr Luiz de Queiroz, Piracicaba - Brazil

• Document type: Journal article
• Source: BRITISH JOURNAL OF NUTRITION; v. 126, n. 12, p. 1794-1808, DEC 28 2021.
• Web of Science Citations: 0

Abstract

Strenuous physical activity, sleep deprivation and psychological stress are common features of military field training. The present study aimed to evaluate the effects of supplementation with a synbiotic ice cream on salivary IgA, gastrointestinal symptoms, well-being indicators and gut microbiota in young military participants undergoing field training. Sixty-five military completed the study: one group was supplemented for 30 d with synbiotic ice cream containing: 2 center dot 1 x 10(8) CFU/g for Lactobacillus acidophilus LA-5 and 2 center dot 7 x 10(9) CFU/g for Bifidobacterium animalis BB-12 and 2 center dot 3 g of inulin in the 60 g of ice cream at manufacture, and the other with a placebo ice cream. Volunteers were evaluated at pre-supplementation (baseline), post-supplementation and after a 5-d military training. Bifidobacterium and Lactobacillus genera were measured in stool samples and both showed a higher differential abundance post-supplementation and training. Salivary IgA and gastrointestinal symptoms decreased at post-training in both groups (P < 0 center dot 05; main effect of time); however, supplementation with synbiotic did not mitigate this effect. Tenseness and sleepiness were decreased in the synbiotic-treated group, but not in the placebo group at post-military training (P = 0 center dot 01 and 0 center dot 009, respectively; group x time effect). The other well-being indicators were not affected by the synbiotic supplementation. In conclusion, 30 d of synbiotic ice cream supplementation containing inulin, L. acidophilus LA-5 and B. animalis BB-12 favourably modulated gut microbiota and improved tenseness and sleepiness in healthy young military undergoing a 5-d field training. These improvements may be relevant to this population as they may influence the decision-making process in an environment of high physical and psychological stress. (AU)

• FAPESP's process: 18/18366-5 - Culture-based and non-culture based techniques for analysis of probiotics and metabolites of the microbiota
• Grantee: Luciana de Carvalho Fino
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/25007-9 - MATRIX EFFECT ON VEHICULATION AND FUNCTIONALITY OF PRE AND PROBIOTICS: STUDY IN A DYNAMIC COLONIC MODEL AND WITH VOLUNTEERS FROM THE PREPARATORY SCHOOL OF ARMY CADETS FROM CAMPINAS
• Grantee: Adriane Elisabete Antunes de Moraes
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants