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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays

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Author(s):
Mussi, Lilian [1] ; Baby, Andre Rolim [2] ; Camargo Junior, Flavio Bueno [1] ; Padovani, Giovana [1] ; Sufi, Bianca da Silva [1] ; Magalhaes, Wagner Vidal [1]
Total Authors: 6
Affiliation:
[1] Chemyun Ltd, Res & Dev Dept, BR-18087101 Sorocaba - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Molecules; v. 26, n. 21 NOV 2021.
Web of Science Citations: 0
Abstract

In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on Cutibacterium acnes. Despite this, we investigated the existence of a synergistic effect among xylitol, caprylic acid and propanediol as a mixture of compounds representing a single topical active ingredient that could benefit the treatment against acne. In vitro and in vivo assays were performed to challenge and to prove the efficacy of propanediol, xylitol and caprylic acid (PXCA) against acne. PXCA had its MIC challenged against C. acnes (formerly Propionibacterium acnes) and Staphylococcus aureus, resulting in concentrations of 0.125% and 0.25%, respectively, and it also developed antimicrobial activity against C. acnes (time-kill test). PXCA was able to reduce the 5-alpha reductase expression in 24% (p < 0.01) in comparison with the testosterone group. By the end of 28 days of treatment, the compound reduced the skin oiliness, porphyrin amount and the quantity of inflammatory lesions in participants. According to the dermatologist evaluation, PXCA improved the skin's general appearance, acne presence and size.</p> (AU)

FAPESP's process: 19/16169-0 - Ex vivo and in vivo establishment of new chemopreventive properties of UV filters
Grantee:André Rolim Baby
Support Opportunities: Regular Research Grants