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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioinformatic reanalysis of public proteomics data reveals that nuclear proteins are recurrent in cancer secretomes

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De Morais, Juliana A. [1] ; Zelanis, Andre [1]
Total Authors: 2
[1] Univ Fed Sao Paulo, UNIFESP, Inst Sci & Technol, Funct Prote Lab, Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: TRAFFIC; v. 23, n. 2 DEC 2021.
Web of Science Citations: 0

Proteins secreted by tumoral cells (cancer secretomes) have been continuously associated with cancer development and progression processes. In this context, secreted proteins contribute to the signaling mechanisms related to tumor growth and spreading and studies on tumor secretomes provide valuable clues on putative tumor biomarkers. Although the in vitro identification of intracellular proteins in cancer secretome studies has usually been associated with contamination derived from cell lysis or fetal bovine serum, accumulated evidence reports on intracellular proteins with moonlighting functions in the extracellular environment. In this study, we performed a systematic reanalysis of public proteomics data regarding different cancer secretomes, aiming to identify intracellular proteins potentially secreted by tumor cells via unconventional secretion pathways. We found a similar repertoire of unconventionally secreted proteins, including the recurrent identification of nuclear proteins secreted by different cancer cells. In addition, in some cancer types, immunohistochemical data were in line with proteomics identifications and suggested that nuclear proteins might relocate from the nucleus to the cytoplasm. Both the presence of nuclear proteins and the likely unconventional secretion of such proteins may comprise biological signatures of malignant transformation in distinct cancer types and may be targeted for further analysis aiming at the prognostic/therapeutic value of such features. (AU)

FAPESP's process: 19/07282-8 - Prospection of markers associated to proteolytic processing in plasma samples of patients with melanoma
Grantee:André Zelanis Palitot Pereira
Support type: Regular Research Grants
FAPESP's process: 14/06579-3 - System-wide analysis of N-terminal processing and protein diversity in the secretome of tumor cells
Grantee:André Zelanis Palitot Pereira
Support type: Research Grants - Young Investigators Grants