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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

xpulsion rates of the levonorgestrel 52 mg intrauterine system are similar among women with heavy menstrual bleeding and users for contraceptio

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Author(s):
Furlani, Rebeca M. [1] ; Garcia, Elaine [1] ; Castro, Sara [1] ; Machado, Helymar C. [1] ; Bahamondes, Luis [1] ; Monteiro, Ilza [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci UNICAMP, Dept Obstet & Gynecol, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Contraception; v. 105, p. 75-79, JAN 2022.
Web of Science Citations: 0
Abstract

Objective: To compare the expulsion rates of the levonorgestrel (LNG) 52 mg intrauterine system (IUS) among women with heavy menstrual bleeding versus women using solely for contraception. Study Design: We conducted an audit study of 548 (8.8%) women with heavy menstrual bleeding and 5655 (91.2%) users for contraception (comparison group) for 4 years in Campinas, Brazil. We retrieved sociodemographic data, expulsion rates, and variables associated to device placement. Among women with heavy menstrual bleeding, we placed the devices after the cessation of bleeding or after the reduction of menstrual flow. Results: Thirty-one of 548 (5.6%) women with heavy menstrual bleeding and 315 of 5655 (5.6%) from the comparison group expelled the device. This constituted 7.8 expulsions/100 women-years in women with heavy menstrual bleeding and 10.3 expulsions/100 women-years from the comparison group ( p = 0.94). Expulsion risk was associated with previous cesarean delivery in both groups (OR 1.93, 95% CI 1.36;2.74). Conclusions: Expulsion rates of the LNG IUS among women with heavy menstrual bleeding whose IUS was placed after the cessation or reduction of bleeding were similar to expulsion rates among users for contraception. Previous cesarean delivery was a risk factor for expulsion. Implications: We recommend the 52 mg LNG IUS placement after the cessation of bleeding or a reduction of menstrual flow among women with heavy menstrual bleeding because this strategy was associated with similar risk of expulsion when compared to users for contraception. (c) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 15/20504-9 - Clinical findings among progestin-only contraceptives' users
Grantee:Luis Guillermo Bahamondes
Support Opportunities: Research Projects - Thematic Grants