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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs

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Author(s):
Macedo, Lucyano J. A. [1] ; Rodrigues, Fernando P. [2] ; Hassan, Ayaz [1] ; Maximo, Leandro N. C. [3] ; Zobi, Fabio [4] ; da Silva, Roberto S. [2] ; Crespilho, Frank N. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Dept Phys & Chem, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Fed Inst Educ, Dept Chem, BR-75790000 Urutuai, Go - Brazil
[4] Univ Fribourg, Dept Chem, Chemin Musee 9, CH-1700 Fribourg - Switzerland
Total Affiliations: 4
Document type: Review article
Source: ANALYTICAL METHODS; DEC 2021.
Web of Science Citations: 0
Abstract

Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing an important role since the last decade because of its great potential to achieve more robust and controlled pharmacological effects against several diseases, including cancer. An important aspect in the development of these drugs is to understand their cellular properties, such as uptake, accumulation, activity, and toxicity. In this review, we present the potential application of micro-FTIR and its importance for studying metal-based drugs, highlighting the perspectives of chemistry of living cells. We also emphasise bioimaging, which is of high importance to localize the cellular processes, for a proper understanding of the mechanism of action. (AU)

FAPESP's process: 19/15333-1 - Bio-photo-electrochemical hybrid cells for solar energy conversion
Grantee:Frank Nelson Crespilho
Support Opportunities: Regular Research Grants
FAPESP's process: 17/20493-2 - Study of metalloenzymes through electrochemistry coupled to vibrational spectroscopy
Grantee:Lucyano Jefferson Alves de Macêdo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/12053-8 - High performance electrodes applied in organic batteries and in biofuel cell
Grantee:Frank Nelson Crespilho
Support Opportunities: Regular Research Grants
FAPESP's process: 19/19448-8 - Effect of photobiomodulation as synergistic addendum on photocytotoxicity of ruthenium-phthalocyanine compounds as nitric oxide and singlet oxygen producers: in vitro biochemical evaluation in two- and three-dimensional (3D) tumor cell lines
Grantee:Roberto Santana da Silva
Support Opportunities: Regular Research Grants