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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plasmodium simium: Population Genomics Reveals the Origin of a Reverse Zoonosis

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Author(s):
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de Oliveira, Thais C. [1] ; Rodrigues, Priscila T. [1] ; Early, Angela M. [2, 3] ; Duarte, Ana Maria R. C. [4, 5] ; Buery, Julyana C. [6] ; Bueno, Marina G. [7, 8] ; Catao-Dias, Jose L. [7] ; Cerutti, Crispim [6] ; Rona, Luisa D. P. [9, 10] ; Neafsey, Daniel E. [2, 3] ; Ferreira, Marcelo U. [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
[2] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA - USA
[3] Broad Inst MIT & Harvard, Infect Dis & Microbiome Program, Cambridge, MA 02142 - USA
[4] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Protozool, Sao Paulo - Brazil
[5] State Secretary Hlth, Lab Biochem & Mol Biol, Superintendency Control Endem SUCEN, Sao Paulo - Brazil
[6] Univ Fed Espirito Santo, Ctr Hlth Sci, Dept Social Med, Vitoria, ES - Brazil
[7] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Lab Wildlife Comparat Pathol, Sao Paulo - Brazil
[8] Fiocruz MS, Lab Comparat & Environm Virol, Oswaldo Cruz Inst, Rio De Janeiro - Brazil
[9] Univ Fed Santa Catarina, Dept Cell Biol Embryol & Genet, Florianopolis, SC - Brazil
[10] Natl Council Sci & Technol Dev, Natl Inst Sci & Technol Mol Entomol, Rio De Janeiro - Brazil
Total Affiliations: 10
Document type: Journal article
Source: Journal of Infectious Diseases; v. 224, n. 11, p. 1950-1961, DEC 1 2021.
Web of Science Citations: 4
Abstract

Background. The population history of Plasmodium simium, which causes malaria in sylvatic Neotropical monkeys and humans along the Atlantic Coast of Brazil, remains disputed. Genetically diverse P vivax populations from various sources, including the lineages that founded the species P simium, are thought to have arrived in the Americas in separate migratory waves. Methods. We use population genomic approaches to investigate the origin and evolution of P simium. Results. We find a minimal genome-level differentiation between P simium and present-day New World P vivax isolates, consistent with their common geographic origin and subsequent divergence on this continent. The meagre genetic diversity in P simium samples from humans and monkeys implies a recent transfer from humans to non-human primates - a unique example of malaria as a reverse zoonosis of public health significance. Likely genomic signatures of P simium adaptation to new hosts include the deletion of > 40% of a key erythrocyte invasion ligand, PvRBP2a, which may have favored more efficient simian host cell infection. Conclusions. New World P vivax lineages that switched from humans to platyrrhine monkeys founded the P simium population that infects nonhuman primates and feeds sustained human malaria transmission in the outskirts of major cities. (AU)

FAPESP's process: 16/18740-9 - Scientific bases for residual malaria elimination in the Brazilian Amazon
Grantee:Marcelo Urbano Ferreira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/10919-4 - Epidemiologic aspects of human and simian malaria in areas of Atlantic Forest in the vicinity of the City of São Paulo: study the Anopheles fauna and natural infection by Plasmodium sp. in Parelheiros and Serra da Cantareira
Grantee:Ana Maria Ribeiro de Castro Duarte
Support Opportunities: Regular Research Grants