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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ntranasal oxygen reverses hypoxaemia in immobilised free-ranging capybaras (Hydrochoerus hydrochaeris

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Author(s):
Cordeiro, Jefferson F. [1] ; Sanches, Mariana C. [1] ; Rusch, Elidiane [1] ; Xavier, V, Nathalia ; Cassoli, Ana Angelica [2] ; Fahlman, Asa [3] ; Carregaro, Adriano B. [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Vet Med Dept, Pirassununga, SP - Brazil
[2] Xavier, Nathalia, V, Univ Sao Paulo, Fac Anim Sci & Food Engn, Vet Med Dept, Pirassununga, SP - Brazil
[3] Swedish Univ Agr Sci SLU, Swedish Biodivers Ctr, Dept Urban & Rural Dev, Uppsala - Sweden
Total Affiliations: 3
Document type: Journal article
Source: PLoS One; v. 16, n. 11 NOV 30 2021.
Web of Science Citations: 0
Abstract

Capybara (Hydrochoerus hydrochaeris) is the main host of tick-borne pathogens causing Brazilian spotted fever; therefore, controlling its population is essential, and this may require chemical restraint. We assessed the impact of chemical restraint protocols on the partial pressure of arterial oxygen (PaO2) and other blood variables in 36 capybaras and the effect of different flows of nasal oxygen (O-2) supplementation. The capybaras were hand-injected with dexmedetomidine (5 mu g/kg) and midazolam (0.1 mg/kg) and butorphanol (0.2 mg/kg) (DMB, n = 18) or methadone (0.1 mg/kg) (DMM, n = 18). One-third of the animals were maintained in ambient air throughout the procedure, and one-third were administered intranasal 2 L/min O-2 after 30 min whereas the other third were administered 5 L/min O-2. Arterial blood gases, acid-base status, and electrolytes were assessed 30 and 60 min after drug injection. The DMB and DMM groups did not vary based on any of the evaluated variables. All animals developed hypoxaemia (PaO2 44 {[}30; 73] mmHg, SaO(2) 81 {[}62; 93] %) 30 min before O-2 supplementation. Intranasal O-2 at 2 L/min improved PaO2 (63 {[}49; 97] mmHg and SaO(2) {[}92 {[}85; 98] %), but 9 of 12 capybaras remained hypoxaemic. A higher O-2 flow of 5 L/min was efficient in treating hypoxaemia (PaO2 188 {[}146; 414] mmHg, SaO(2) 100 {[}99; 100] %) in all the 12 animals that received it. Both drug protocols induced hypoxaemia, which could be treated with intranasal oxygen supplementation. (AU)

FAPESP's process: 16/21121-9 - Reversible protocols of chemical restraint in wild capybaras (Hydrochoerus hydrochaeris)
Grantee:Jefferson Farias Cordeiro
Support Opportunities: Scholarships in Brazil - Doctorate