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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TRPV1 blockers as potential new treatments for psychiatric disorders

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Iglesias, Lia P. [1, 2] ; Aguiar, Daniele C. [1, 2] ; Moreira, Fabricio A. [1, 2]
Total Authors: 3
[1] Univ Fed Minas Gerais, Grad Sch Neurosci, Dept Pharmacol, Belo Horizonte, MG - Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG - Brazil
Total Affiliations: 2
Document type: Review article
Source: Behavioural Pharmacology; v. 33, n. 1, p. 2-14, FEB 2022.
Web of Science Citations: 0

The transient receptor potential vanilloid-1 channel (TRPV1) is responsible for decoding physical and chemical stimuli. TRPV1 is activated by capsaicin (a compound from chili peppers), heat (above 43 degrees C) and acid environment, playing a major role in pain, inflammation and body temperature. Molecular and histological studies have suggested TRPV1 expression in specific brain regions, where it can be activated primarily by the endocannabinoid anandamide, fostering studies on its potential role in psychiatric disorders. TRPV1 blockers are effective in various animal models predictive of anxiolytic and antipanic activities, in addition to reducing conditioned fear. In models of antidepressant activity, these compounds reduce behavioral despair and promote active stress-coping behavior. TRPV1 blockers also reduce the effects of certain drugs of abuse and revert behavioral changes in animal models of neurodevelopmental disorders. The main limiting factor in developing TRPV1 blockers as therapeutic agents concerns their effects on body temperature, particularly hyperthermia. New compounds, which block specific states of the channel, could represent an alternative. Moreover, compounds blocking both TRPV1 and the anandamide-hydrolyzing enzyme, fatty acid amide hydrolase (FAAH), termed dual TRPV1/FAAH blockers, have been investigated with promising results. Overall, preclinical studies yield favorable results with TRPV1 blockers in animal models of psychiatric disorders. (AU)

FAPESP's process: 17/24304-0 - New perspectives in the use of drugs that modify atypical neurotransmitters in the treatment of neuropsychiatric disorders
Grantee:Francisco Silveira Guimaraes
Support type: Research Projects - Thematic Grants