apping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazi

Author(s):Show less -

Li, Sabrina L. ^[1] ; Acosta, Andre L. ^[2] ; Hill, Sarah C. ^[3] ; Brady, Oliver J. ^{[4, 5]} ; de Almeida, Marco A. B. ^[6] ; Cardoso, Jader da C. ^[6] ; Hamlet, Arran ^[7] ; Mucci, Luis F. ^[8] ; de Deus, Juliana Telles ^[8] ; Iani, Felipe C. M. ^[9] ; Alexander, Neil S. ^[10] ; Wint, G. R. William ^[10] ; Pybus, Oliver G. ^{[11, 3]} ; Kraemer, Moritz U. G. ^[11] ; Faria, Nuno R. ^{[11, 12, 13, 7]} ; Messina, Jane P. ^{[1, 14]}

Affiliation:Show less -

^[1] Univ Oxford, Sch Geog & Environm, Oxford - England

^[2] Univ Sao Paulo, Dept Ecol, Inst Biociencias, Lab Ecol Paisagens & Conservacao LEPAC, Sao Paulo - Brazil

^[3] Royal Vet Coll London, Dept Pathobiol & Populat Sci, London - England

^[4] London Sch Hyg & Trop Med, Ctr Math Modelling Infect Dis, London - England

^[5] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Dept Infect Dis Epidemiol, London - England

^[6] Rio Grande State Hlth Secretariat, State Ctr Hlth Surveillance, Porto Alegre, RS - Brazil

^[7] Imperial Coll London, Dept Infect Dis Epidemiol, MRC Ctr Global Infect Dis Anal, London - England

^[8] Sao Paulo State Hlth Secretariat, Superintendence Endem Dis Control, Sao Paulo - Brazil

^[9] Fundacao Ezequiel Dias, Lacen, MG - Brazil

^[10] Univ Oxford, Environm Res Grp Oxford, Dept Zool, Oxford - England

^[11] Univ Oxford, Dept Zool, Oxford - England

^[12] Univ Sao Paulo, Inst Med Trop, Fac Med, Sao Paulo - Brazil

^[13] Univ Sao Paulo, Dept Molestias Infecciosas & Parasitarias, Sao Paulo - Brazil

^[14] Univ Oxford, Oxford Sch Global & Area Studies, Oxford - England

• Document type: Journal article
• Source: PLoS Neglected Tropical Diseases; v. 16, n. 1 JAN 2022.
• Web of Science Citations: 0

Abstract

Author summaryYellow fever virus (YFV) is an arbovirus transmitted to humans from mosquitoes and can lead to severe disease and death. Recent sporadic outbreaks coupled with low vaccination coverage have highlighted the importance of mosquito surveillance for preventing future outbreaks and potential virus spillover into dense urban areas. Yet, very little is known about the spatial distribution of mosquitoes known to transmit YFV and the factors that contribute to their environmental suitability in Brazil. We compiled an occurrence database of primary and secondary mosquito vectors belonging to Haemagogus and Sabethes species' collected between 1991-2019 and integrated this data with environmental and land-use data to predict their spatial suitability at 1x1km resolution. Using this information, we identified suitable regions for their co-existence. We overlaid this information with human population density and locations of non-human primate host reservoirs to identify areas at risk of transmission and spillover. Our study provides high-resolution mapping tools to assist with mosquito and arbovirus surveillance which is especially useful in low-resource settings. BackgroundYellow fever (YF) is an arboviral disease which is endemic to Brazil due to a sylvatic transmission cycle maintained by infected mosquito vectors, non-human primate (NHP) hosts, and humans. Despite the existence of an effective vaccine, recent sporadic YF epidemics have underscored concerns about sylvatic vector surveillance, as very little is known about their spatial distribution. Here, we model and map the environmental suitability of YF's main vectors in Brazil, Haemagogus spp. and Sabethes spp., and use human population and NHP data to identify locations prone to transmission and spillover risk. Methodology/Principal findingsWe compiled a comprehensive set of occurrence records on Hg. janthinomys, Hg. leucocelaenus, and Sabethes spp. from 1991-2019 using primary and secondary data sources. Linking these data with selected environmental and land-cover variables, we adopted a stacked regression ensemble modelling approach (elastic-net regularized GLM, extreme gradient boosted regression trees, and random forest) to predict the environmental suitability of these species across Brazil at a 1x1 km resolution. We show that while suitability for each species varies spatially, high suitability for all species was predicted in the Southeastern region where recent outbreaks have occurred. By integrating data on NHP host reservoirs and human populations, our risk maps further highlight municipalities within the region that are prone to transmission and spillover. Conclusions/SignificanceOur maps of sylvatic vector suitability can help elucidate potential locations of sylvatic reservoirs and be used as a tool to help mitigate risk of future YF outbreaks and assist in vector surveillance. Furthermore, at-risk regions identified from our work could help disease control and elucidate gaps in vaccination coverage and NHP host surveillance. (AU)

• FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
• Grantee: Ester Cerdeira Sabino
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/12988-7 - Mosquito species identification, blood meal and virus detection using Oxford Nanopore technologies' (MinION) in a YF transmission scenario
• Grantee: André Luis Acosta
• Support Opportunities: Scholarships in Brazil - Post-Doctoral