| Full text | |
| Author(s): |
Monteiro, Diana Amaral
[1]
;
Kalinin, Ana Lucia
[1]
;
Selistre-de-Araujo, Heloisa Sobreiro
[1]
;
Rantin, Francisco Tadeu
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Carlos UFSCar, Ctr Ciencias Biol & Saude CCBS, Dept Ciencias Fisiol DCF, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Toxicon; v. 205, p. 67-70, JAN 2022. |
| Web of Science Citations: | 0 |
| Abstract | |
The aim of this study was to evaluate the effects of different doses of alternagin-C, a disintegrin-like protein from Rhinocerophis alternatus venom, on myocardial contractility of the freshwater fish Hoplias malabaricus, an alternative model to contractile function studies. Alternagin-C treatment exhibited a hormetic-like dose-response curve with a strong positive inotropism and enhanced cardiac pumping capacity at low dose, whereas a modest inotropism and a left shift in the force-frequency relationship was registered at high dose. (AU) | |
| FAPESP's process: | 13/00798-2 - The extracellular matrix in aging, exercise and in the tumor microenvironment |
| Grantee: | Heloisa Sobreiro Selistre de Araújo |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/10993-4 - Effects of alternagin-C (ALT-C), a protein from venom of urutu snake (Rhinocerophis alternatus, previously known Bothrops alternatus), on fish cardiac contractility under normoxia and against tissue hypoxia |
| Grantee: | Diana Amaral Monteiro |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |