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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ostsynaptic cleft density changes with combined exercise protocols in an experimental model of muscular hypertroph

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Author(s):
Neto, Jurandyr Pimentel [1] ; Rocha, Lara Caetano [1] ; Jacob, Carolina dos Santos [1] ; Barbosa, Gabriela Klein [1] ; Ciena, Adriano Polican [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci IB, Lab Morphol & Phys Act LAMAF, Ave 24A 1515, BR-13506900 Rio Claro, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: EUROPEAN JOURNAL OF HISTOCHEMISTRY; v. 65, n. 1, SI 2021.
Web of Science Citations: 0
Abstract

The vertical ladder-based protocols contribute to the NMJ junction's adaptations, and when combined with and without load, can be potentiated. The present study aimed to investigate postsynaptic regions of the biceps brachii muscle in adult male Wistar rats submitted to different vertical ladder-based protocols (Sedentary - S; Climbing - C; Climbing with Load - LC and Combined Climbing - CC). The protocols (C, LC, CC) were performed in 24 sessions, 3 x/week, for 8 weeks. The myofibrillar ATPase analysis showed an increase in crosssectional area (CSA) of the muscle fibers Type I in all trained Groups; Type II in C and LC and reduction in CC; Type IIx higher in all trained Groups. In the postsynaptic cleft, the stained area presents smaller in Groups C, LC, and CC; the total area showed smaller than LC and higher in C and CC. The stained and total perimeter, and dispersion showed a reduction in C, LC, and CC, higher maximum diameter in Groups C and CC, and decreased in LC. Regarding the postsynaptic cleft distribution, the stained area presented a decrease in all trained Groups. The integrated density presented higher principally in CC. The NMJ count showed an increase in all trained Groups. We concluded that the vertical ladder-based protocols combined contributed to the postsynaptic region adaptations. (AU)

FAPESP's process: 17/12525-1 - Plasticity at the myotendinous junction of adult rats subjected to stretching, associated with hypertrophy and swimming training: morphological, molecular and functional analyzes, with new perspectives about sarcomerogenesis
Grantee:Adriano Polican Ciena
Support Opportunities: Regular Research Grants
FAPESP's process: 17/21977-3 - Adaptations to the lengths of the sarcomeres in the region of the myotendinous junction of the plantar muscle associated to physical exercise
Grantee:Jurandyr Pimentel Neto
Support Opportunities: Scholarships in Brazil - Scientific Initiation