The role of the oviduct and extracellular vesicles during early embryo development in bovine

Author(s)

Natália Marins Bastos ^[1] ; Juliana Germano Ferst ^[2] ; Rodrigo Silva Goulart ^[3] ; Juliano Coelho da Silveira ^[4]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil

^[2] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil

^[3] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Zootecnia - Brasil

^[4] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil

• Document type: Journal article
• Source: Animal Reproduction; v. 19, n. 1 2022-04-20.

Abstract

Abstract The oviduct is an important reproductive structure that connects the ovary to the uterus and takes place to important events such as oocyte final maturation, fertilization and early embryonic development. Thus, gametes and embryo can be directly influenced by the oviductal microenvironment composed by epithelial cells such secretory and ciliated cells and oviductal fluid. The oviduct composition is anatomically dynamic and is under ovarian hormones control. The oviductal fluid provides protection, nourishment and transport to gametes and embryo and allows interaction to oviductal epithelial cells. All these functions together allows the oviduct to provides the ideal environment to the early reproductive events. Extracellular vesicles (EVs) are biological nanoparticles that mediates cell communication and are present at oviductal fluid and plays an important role in gametes/embryo - oviductal cells communication. This review will present the ability of the oviducts based on its dynamic and systemic changes during reproductive events, as well as the contribution of EVs in this process. (AU)

• FAPESP's process: 20/13075-2 - Dairy cows metabolic status effects on epigenetic changes in the embryo and endometrium: the role of extracellular vesicles
• Grantee: Juliana Germano Ferst
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 20/08478-0 - Hormonal influences and body energy reserve on the modulation of the intrafolicular and periconceptional reproductive environment
• Grantee: Juliano Coelho da Silveira
• Support type: Regular Research Grants
• FAPESP's process: 15/21829-9 - Multi-user equipment approved in grant 2014/22887-0: Nanosight LM10
• Grantee: Juliano Coelho da Silveira
• Support type: Multi-user Equipment Program
• FAPESP's process: 14/22887-0 - Cell-secreted vesicles containing miRNAs modulate epigenetic changes during in vitro culture of bovine gametes and embryos
• Grantee: Juliano Coelho da Silveira
• Support type: Research Grants - Young Investigators Grants