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Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function

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Prudencio, Caroline Baldini ; Nunes, Sthefanie Kenickel ; Pinheiro, Fabiane Affonso ; Sartorao Filho, Carlos Isaias ; Antonio, Flavia Ignacio ; de Aquino Nava, Guilherme Thomaz ; Cunha Rudge, Marilza Vieira ; Pascon Barbosa, Angelica Mercia ; Diamater Study Grp
Total Authors: 9
Document type: Journal article
Source: INTERNATIONAL UROGYNECOLOGY JOURNAL; v. N/A, p. 9-pg., 2022-06-03.

Introduction and hypothesis To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association's diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0-2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3-5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0-2 compared to the other three groups. Conclusions Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups. (AU)

FAPESP's process: 21/10665-6 - Effectiveness of the pelvic floor muscle training in aquatic ambient on pelvic floor muscle function and pregnancy specific urinary incontinence in pregnant women with Gestational Diabetes Mellitus: a feasibility study to randomized controlled trial
Grantee:Caroline Baldini Prudencio
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats
Grantee:Marilza Vieira Cunha Rudge
Support Opportunities: Research Projects - Thematic Grants