Histone Modification on Parathyroid Tumors: A Review of Epigenetics

Author(s)

Conti de Freitas, Luiz C. ; Castilho, Rogerio M. ; Squarize, Cristiane H.

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 10, p. 10-pg., 2022-05-01.

Abstract

Parathyroid tumors are very prevalent conditions among endocrine tumors, being the second most common behind thyroid tumors. Secondary hyperplasia can occur beyond benign and malignant neoplasia in parathyroid glands. Adenomas are the leading cause of hyperparathyroidism, while carcinomas represent less than 1% of the cases. Tumor suppressor gene mutations such as MEN1 and CDC73 were demonstrated to be involved in tumor development in both familiar and sporadic types; however, the epigenetic features of the parathyroid tumors are still a little-explored subject. We present a review of epigenetic mechanisms related to parathyroid tumors, emphasizing advances in histone modification and its perspective of becoming a promising area in parathyroid tumor research. (AU)

• FAPESP's process: 21/09810-1 - Characterization of the H3K9 histone acetylation profile in surgical pathologies of the parathyroid glands
• Grantee: Luiz Carlos Conti de Freitas
• Support Opportunities: Scholarships abroad - Research