| Full text | |
| Author(s): |
van Oirschot, Bart A. J. A.
;
Zhang, Yang
;
Alghamdi, Hamdan S.
;
Cordeiro, Jairo M.
;
Nagay, Bruna E.
;
Barao, Valentim A. R.
;
de Avila, Erica Dorigatti
;
van den Beucken, Jeroen J. J. P.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | TISSUE ENGINEERING PART A; v. 28, n. 11-12, p. 18-pg., 2022-06-01. |
| Abstract | |
Dental implants represent an illustrative example of successful medical devices used in increasing numbers to aid (partly) edentulous patients. Particularly in spite of the percutaneous nature of dental implant systems, their clinical success is remarkable. This clinical success is at least partly related to the effective surface treatment of the artificial dental root, providing appropriate physicochemical properties to achieve osseointegration. The demographic changes in the world, however, with a rapidly increasing life expectancy and an increase in patients suffering from comorbidities that affect wound healing and bone metabolism, make that the performance of dental implants requires continuous improvement. An additional factor endangering the clinical success of dental implants is peri-implantitis, which affects both the soft and hard tissue interactions with dental implants. In this study, we shed light on the optimization of dental implant surfaces through surface engineering. Depending on the region along the artificial dental root, different properties of the surface are required to optimize prevailing tissue response to facilitate osseointegration, improve soft tissue attachment, and exert antibacterial efficacy. As such, surface engineering represents an important tool for assuring the continued future success of dental implants. Impact StatementDental implants represent a common treatment modality nowadays for the replacement of lost teeth or fixation of prosthetic devices. This review provides a detailed overview of the role of surface engineering for dental implants and their components to optimize tissue responses at the different regions along the artificial dental root. The surface properties steering immunomodulatory processes, facilitating osseointegration, and rendering antibacterial efficacy (at both artificial root and abutment region) are described. The review finally concludes that surface engineering provides a tool to warrant that dental implants will remain future proof in more challenging applications, including an aging patient population and comorbidities that affect bone metabolism and wound healing. (AU) | |
| FAPESP's process: | 20/05231-4 - Development of a new thermosensitive hydrogel for controlled release of drugs to prevent and treat peri-implant inflammations |
| Grantee: | Valentim Adelino Ricardo Barão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/20719-3 - A novel antimicrobial drug-delivery coating for percutaneous implant devices |
| Grantee: | Érica Dorigatti de Avila |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 21/09434-0 - A novel antimicrobial drug-delivery coating for percutaneous implant devices |
| Grantee: | Érica Dorigatti de Avila |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 19/17238-6 - Antibacterial coating with photocatalytic potential under visible light for dental implants: in vitro, in situ and in vivo studies |
| Grantee: | Bruna Egumi Nagay |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/01320-0 - Development of a bioactive and antibacterial surface containing Cu2O for dental implants |
| Grantee: | Jairo Matozinho Cordeiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/03567-7 - Modification of the physicochemical properties with different coating materials of titanium implant abutment surfaces and evaluation of their effects on the development of a polymicrobial community representative of the oral cavity: an in vitro preliminar |
| Grantee: | Érica Dorigatti de Avila |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |