Effects of diabetes between generations on the pre... - BV FAPESP
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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of diabetes between generations on the pre-embryos of rats

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Author(s):
VINÍCIUS S. BARCO [1] ; FRANCIANE Q. GALLEGO [2] ; VERÔNYCA G. PAULA [3] ; LARISSA L. CRUZ ; BARSHANA KARKI [5] ; GUSTAVO T. VOLPATO [6] ; DÉBORA C. DAMASCENO [7]
Total Authors: 7
Affiliation:
[1] Universidade Estadual Paulista (UNESP). Programa de Pós-Graduação em Tocoginecologia - Brasil
[2] Universidade Estadual Paulista (UNESP). Programa de Pós-Graduação em Tocoginecologia - Brasil
[3] Universidade Estadual Paulista (UNESP). Programa de Pós-Graduação em Tocoginecologia - Brasil
[5] Universidade Estadual Paulista (UNESP). Programa de Pós-Graduação em Tocoginecologia - Brasil
[6] Universidade Federal do Mato Grosso (UFTM). Instituto de Ciências Biológicas e da Saúde - Brasil
[7] Universidade Estadual Paulista (UNESP). Programa de Pós-Graduação em Tocoginecologia - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Anais da Academia Brasileira de Ciências; v. 94, 2022-12-12.
Abstract

Abstract Pregestational hyperglycemia cause adverse effects on mothers and their offspring. We aimed to evaluate the maternal hyperglycemia influence on pre-embryos from diabetic rats and on their generations (daughters and granddaughters). Diabetes was induced in Sprague-Dawley rats. The mothers and their female pups were submitted to oral glucose tolerance test in adulthood. In day 4 of pregnancy, pre-embryos were collected for morphological analysis. The diabetic mother, daughter and granddaughter rats showed glucose intolerance and their pre-embryos presented developmental delay, degeneration and losses compared to the nondiabetic group. Thus, maternal diabetes transgenerationally affects embryos at early development, which contributes for embryofetal losses. (AU)

FAPESP's process: 16/25207-5 - Evaluation of offspring exposed to mildly diabetic intrauterine millieu, submitted to postnatal hyperlipid diet and treated with a mixture of calcium and vitamin D during pregnancy.
Grantee:Débora Cristina Damasceno
Support Opportunities: Regular Research Grants