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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of BlueM® against Streptococcus mutans biofilm and its virulence gene expression

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Author(s):
Veronica Canela Estevam dos Santos [1] ; Patricia Milagros Maquera-Huacho [2] ; Maria Júlia Mancim Imbriani ; Vivian M. Tellaroli Rodrigues Minhaco ; Denise M. Palomari Spolidorio [5]
Total Authors: 5
Affiliation:
[1] São Paulo State University. School of Dentistry. Department of Physiology and Pathology - Brasil
[2] São Paulo State University. School of Dentistry. Department of Physiology and Pathology - Brasil
[5] São Paulo State University. School of Dentistry. Department of Physiology and Pathology - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Brazilian Dental Journal; v. 34, n. 1, p. 19-28, 2023-03-06.
Abstract

Abstract This study evaluated the antimicrobial capacity of BlueM® mouthwash against the bacterium Streptococcus mutans and its influence on gbpA gene expression as well as its cytotoxic effect on fibroblast cells. BlueM® showed antimicrobial activity, with MIC and MBC values of 0.005% and 0.01%, respectively. The MBIC was 6.25% for S. mutans. CFU count and confocal microscopy revealed significant effect of BlueM® on S. mutans biofilm pre-formed on dentin surfaces. Interestingly, the analysis of gbpA gene expression indicated a decrease in gene expression after 15 min of treatment with BlueM® at a concentration of 25%. Moreover, BlueM® exhibited low levels of cytotoxicity. In conclusion, our results showed the antimicrobial effectiveness of BlueM® against S. mutans, its ability to modulate the expression of the gbpA gene and its low cytotoxicity. This study supports the therapeutic potential of BlueM® as an alternative agent for the control of oral biofilm. (AU)

FAPESP's process: 19/25534-4 - Effect of active oxygen on Streptococcus mutans biofilm
Grantee:Veronica Canela Estevam dos Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation