Circulating molecules that control brown/beige adipocyte differentiation and thermogenic capacity

Author(s)

Ludwig, Raissa G. ; Rocha, Andrea L. ; Mori, Marcelo A.

• Document type: Journal article
• Source: Cell Biology International; v. 42, n. 6, p. 10-pg., 2018-06-01.

Abstract

Obesity may be counteracted by increased energy expenditure. Circulating molecules act in the adipose tissue to influence brown and beige adipocyte function, differentiation, and thermogenic capacity, which in turn affects substrate utilization and impacts energy balance at the organismal level. These molecules have been envisioned as biomarkers and potential candidates for pharmacological interventions to treat obesity. Here we summarize studies that demonstrate the roles of endogenous circulating molecules of a wide variety in regulating the thermogenic potential of brown and beige fat cells. This review describes the state-of-the-art in the field and helps researchers to prioritize their targets in future studies. (AU)

• FAPESP's process: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics
• Grantee: Marcelo Alves da Silva Mori
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/07975-8 - Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training
• Grantee: Marcelo Alves da Silva Mori
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/20822-0 - Metabolic characterization of adipocytes in response to serum of rodents subjected to dietary restriction
• Grantee: Raissa Guimarães Ludwig
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 16/12294-7 - Dicer signalling in adipocytes controlling immune function and activation of beige cells in adipose tissue
• Grantee: Andréa Livia Silva Rocha
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/01316-7 - Dicer, miRNAs and the control of mitochondrial function in the context of aging and caloric restriction
• Grantee: Marcelo Alves da Silva Mori
• Support Opportunities: Regular Research Grants