Increased Prevalence of Depression and Anxiety Amo... - BV FAPESP
Advanced search
Start date
Betweenand


Increased Prevalence of Depression and Anxiety Among Subjects With Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Full text
Author(s):
Show less -
Berto, Laura F. ; Suemoto, Claudia K. ; Moreno, Arlinda B. ; Fonseca, Maria de Jesus M. ; Nunes, Maria Angelica A. ; Molina, Maria del Carmen B. ; Barreto, Sandhi M. ; Diniz, Maria de Fatima Haueisen Sander ; Lotufo, Paulo A. ; Bensenor, Isabela M. ; Brunoni, Andre R.
Total Authors: 11
Document type: Journal article
Source: JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY; v. 63, n. 6, p. 10-pg., 2022-12-14.
Abstract

Background: Metabolic syndrome (MetS) and common mental disorders are prevalent conditions. However, the relationship of MetS and its components with depression, anxiety, and common mental disorders has not been suf-ficiently addressed in low-/middle-income countries. Objective: To investigate whether depression, anxiety, and common mental disorders are associated with MetS and its components in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: A cross-sectional analysis of the ELSA-Brasil baseline visit (2008-2010) was performed. Adults without cardiovascular diseases had their MetS status defined by the National Cholesterol Ed-ucation Program's Adult Treatment Panel III criteria. We assessed mental disorders using the Clinical Interview Schedule-Revised. We employed multiple logistic regres-sion models adjusted for sociodemographic and behavioral factors. The dependent variables were mental disorders, and the independent variables were MetS and its components. We also performed analyses stratified by age and gender. Results: Our sample included 12,725 participants (54.9% women, mean age of 51.8 +/- 8.9 y). MetS and depressive disorders were significantly associated (odds ratio [OR] = 1.55, 95% confidence interval [CI] 1.30-1.85). Increased abdominal circumference (OR = 1.54, 95% CI 1.29-1.84), diabetes mellitus (OR = 1.24, 95% CI 1.02-1.50), hypertriglyceridemia (OR = 1.33, 95% CI 1.11-1.60), and low high-density lipoprotein cholesterol (only when adjusted for sociodemographic factors) (OR = 1.25, 95% CI 1.02-1.52) were also associated with depression. This association remained significant for all stratified analyses. Finally, MetS was also significantly associated with anxiety disorders (OR = 1.19, 95% CI 1.07-1.32) and common mental disorders (OR = 1.27, 95% CI 1.17-1.39). Conclusions: Our cross-sectional findings suggested that depression, anxiety, and common mental disorder are associated with MetS. Depression was also associated with abdominal obesity, elevated blood glucose, elevated triglycerides, and reduced high-density lipoprotein cholesterol, but not with hypertension. (Journal of the Academy of Consultation-Liaison Psy-chiatry 2022; 63:529-538) (AU)

FAPESP's process: 20/06887-0 - Association between the prevalence of Depressive and anxious disorders and metabolic Syndrome: a cross-sectional analysis on ELSA- Brasil (The Brazilian Longitudinal Study of Adult Health)
Grantee:Laura Fernandes Berto
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/06009-6 - Non-implantable neuromodulation therapies: a perspective for the depressed brain
Grantee:Andre Russowsky Brunoni
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/10861-7 - A Phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning
Grantee:Andre Russowsky Brunoni
Support Opportunities: Regular Research Grants