Dissection of the lipoic acid metabolism as druggable target in Malaria
EMU 2015/26722-8 AVANTI J-30 I Biosafe centrifuge including rotor
Full text | |
Author(s): |
Rei Yan, Sun Liu
;
Wakasuqui, Felipe
;
Du, Xiaochen
;
Groves, Matthew R.
;
Wrenger, Carsten
Total Authors: 5
|
Document type: | Journal article |
Source: | RONTIERS IN CHEMISTR; v. 9, p. 7-pg., 2021-11-04. |
Abstract | |
Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases. (AU) | |
FAPESP's process: | 17/26358-0 - Dissection of the lipoic acid metabolism as druggable target in Malaria |
Grantee: | Sun Liu Rei Yan |
Support Opportunities: | Scholarships in Brazil - Doctorate |
FAPESP's process: | 15/26722-8 - Drug discovery against human infectious diseases |
Grantee: | Carsten Wrenger |
Support Opportunities: | Research Projects - Thematic Grants |
FAPESP's process: | 17/03966-4 - Targeting lipoic acid salvage and biosynthesis pathways in MRSA |
Grantee: | Carsten Wrenger |
Support Opportunities: | Regular Research Grants |