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Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

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Author(s):
Rei Yan, Sun Liu ; Wakasuqui, Felipe ; Du, Xiaochen ; Groves, Matthew R. ; Wrenger, Carsten
Total Authors: 5
Document type: Journal article
Source: RONTIERS IN CHEMISTR; v. 9, p. 7-pg., 2021-11-04.
Abstract

Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases. (AU)

FAPESP's process: 17/26358-0 - Dissection of the lipoic acid metabolism as druggable target in Malaria
Grantee:Sun Liu Rei Yan
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/26722-8 - Drug discovery against human infectious diseases
Grantee:Carsten Wrenger
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/03966-4 - Targeting lipoic acid salvage and biosynthesis pathways in MRSA
Grantee:Carsten Wrenger
Support Opportunities: Regular Research Grants