Thermal analysis of tetracyclines: a review

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Author(s):	de Freitas, Jonatha ; Ferreira, Ana Paula Garcia ; Cavalheiro, Eder Tadeu Gomes Total Authors: 3
Document type:	Journal article
Source:	JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. N/A, p. 13-pg., 2023-06-24.
Abstract
A revision on articles concerning thermal analysis of tetracyclines is presented, regarding drug-excipient compatibility, characterization of drug releasing systems, physicochemical behavior of drug-supported systems and degradation of some pharmaceuticals itself. Initially, an overview of information regarding this class of drugs is presented. A bibliographic survey revealed relatively few works on this subject despite the worldwide use and relevance of this class of antibiotics. Here, 37 papers published during the time frame 2000-2022 were classified as above and discussed once they presented thermoanalytical data straightly related to the tetracyclines. From the thermal studies of the drugs, a general decomposition behavior could be identified and it is presented. (AU)

FAPESP's process:	19/22217-8 - Thermoanalytical studies applied to antihepatitis and antiretroviral drugs of the protease inhibitor class: thermal behavior, decomposition intermediates, volatile characterization and polymorphism
Grantee:	Éder Tadeu Gomes Cavalheiro
Support Opportunities:	Regular Research Grants