Hydrolyzed collagen interferes with in vitro photoprotective effectiveness of sunscreens

Author(s)

Peres, Daniela D'Almeida ; Hubner, Alexandra ; de Oliveira, Camila Areias ; de Almeida, Tania Santos ; Kaneko, Telma Mary ; Consiglieri, Vladi Olga ; Sales de Oliveira Pinto, Claudineia Aparecida ; Robles Velasco, Maria Valeria ; Baby, Andre Rolim

• Document type: Journal article
• Source: Brazilian Journal of Pharmaceutical Sciences; v. 53, n. 2, p. 7-pg., 2017-01-01.

Abstract

The chronological skin aging is a progressive and natural process with genetic and physiological changes. However, ultraviolet (UV) radiation may accelerate the oxidative stress, generating carcinogenesis and photoaging. Natural compounds and their applications are considered a trend in the cosmetic market. The protein-based film-forming compounds play an important role, once it collaborates for the better distribution of sunscreens on the skin. Here we investigated the in vitro photoprotective effectiveness of sunscreens containing the hydrolyzed collagen associated with UVA, UVB and/or inorganic filters. Sunscreens were developed with octocrylene (7.5%), butyl methoxydibenzoylmethane (avobenzone) (3.0%) and/or titanium dioxide (5.0%), associated or not with the hydrolyzed collagen (3.0%). In vitro photoprotective effectiveness was determined in a Labsphere (R) UV2000S by the establishment of the sun protection factor (SPF) and critical wavelength (nm) values. Physicochemical and organoleptic characteristics were also assayed. The hydrolyzed collagen subjectively improved the formulation sensory characteristics. However, this bioactive compound led to a decrease of the SPF values of the photoprotective formulations containing octocrylene alone and octocrylene + butyl methoxydibenzoylmethane + TiO2. This inadequate interaction may be considered during the development of new sunscreens intended to contain protein-based components. (AU)

• FAPESP's process: 10/10739-5 - Rutin for application in sunscreens: electronic interaction with UV filters, antioxidant activity and "in vitro" efficacy
• Grantee: André Rolim Baby
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/19972-0 - Technological development, safety assessment and clinical effectiveness of rutin-loaded gelatin micro/nanoparticles
• Grantee: Camila Areias de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)